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GenomicsGenome-Wide Association Studies in Upper Gastrointestinal Cancers (Asian)

This project aims to conduct genome-wide association studies (GWAS) in two anatomically different upper gastrointestinal (UGI) cancer sites in two populations with distinctly different disease rates and genetic profiles. One population has very high rates for both esophageal squamous cel...

phs000361.v1.p1 | EGA
ProteomicsAnti-Toxoplasma gondii effect of vorinostat in vitro and in vivo
Toxoplasma gondii is an important pathogenic protozoon that infects up to one-third of the world's population. In immunocompetent individuals, the infection generally is asymptomatic. However, in immunocompromised patients, the infection can lead to severe and fatal complications. This is due to the...
ORGANISM(S): Toxoplasma Gondii Rh-88 
2024-07-17 | PXD053997 |
ProteomicsSortilin-mediated translocation of mitochondrial ACSL1 impairs adipocyte thermogenesis and energy expenditure in male mice
Beige fat activation involves a fuel switch to fatty acid oxidation following chronic cold adaptation. Mitochondrial acyl-CoA synthetase long-chain family member 1 (ACSL1) localizes in the mitochondria and plays a key role in fatty acid oxidation; however, the regulatory mechanism of the subcellular...
ORGANISM(S): Mus Musculus 
2024-08-16 | PXD055014 |
ProteomicsMi-2β promotes immune evasion in melanoma by activating EZH2 methylation
For identification of Mi-2β-interacting proteins, B16F10 cells (1 × 108) were collected and washed three times with PBS and lysed in lysis buffer on ice for 30 min. Cell lysates were collected and then isolated over night by anti-Mi-2β magnetic agarose beads. The anti-Mi-2β magnetic agarose beads we...
ORGANISM(S): Mus Musculus 
2024-02-18 | PXD049467 |
ProteomicsTargeting vulnerable microcircuit in the ventral hippocampus of male transgenic mice to rescue Alzheimer-like social memory loss
Background:Episodic memory loss is a prominent clinical manifestation of Alzheimer's disease(AD), which is closely related to tau pathology and hippocampal impairment. Given the heterogeneity of brain neurons, the precise role of different brain neurons in terms of their sensitivity to tau accumulat...
ORGANISM(S): Mus Musculus 
2023-07-19 | PXD043883 |
UnknownEffects of empagliflozin on quality of life and healthcare use and costs in chronic kidney disease: a health economic analysis of the EMPA-KIDNEY trial.
Not available
S-EPMC12274867 | biostudies-literature
UnknownFrailty, Multimorbidity, and Polypharmacy: Exploratory Analyses of the Effects of Empagliflozin from the EMPA-KIDNEY Trial.
Not available
S-EPMC11390031 | biostudies-literature
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