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ProteomicsInner membrane complex proteomics reveals a palmitoylation cascade regulating intraerythrocytic development of malaria parasite
Malaria is caused by infection of the erythrocytes by the parasites Plasmodium. Inside the erythrocytes, the parasites grow and multiply via schizogony, an unconventional cell division mode. The Inner Membrane Complex (IMC), an organelle located beneath the plasma membrane of the parasites, is essen...
ORGANISM(S): Plasmodium Yoelii Yoelii 17xnl 
2022-07-01 | PXD028193 |
ProteomicsApical anchorage and stabilization of subpellicular microtubules by apical polar ring ensures Plasmodium ookinete infection in mosquito
Morphogenesis of many protozoans depends on a polarized establishment of cortical cytoskeleton possessing the subpellicular microtubules (SPMTs), which are apically nucleated and anchored by the apical polar ring (APR). In the malaria parasite Plasmodium, APR can be observed when a round zygote diff...
ORGANISM(S): Plasmodium Yoelii Yoelii 17xnl 
2022-11-18 | PXD038209 |
ProteomicsCleavage of CAD by caspase-3 determines the cancer cell fate during chemotherapy
Metabolic heterogeneity resulting from the intrinsic heterogeneity of human tumors has been shown to cause a myriad of adverse outcomes of tumor therapy, including resistance to chemotherapy, but the mechanisms inside remain largely unknown. Here, we found that the de novo pyrimidine synthesis pathw...
ORGANISM(S): Homo Sapiens 
2025-01-01 | PXD059365 |
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