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MetabolomicsLiver-specific paraoxonase-1 alleviates regulatory T cell-driven immunosuppression via metabolic reprogramming in hepatocellular carcinoma

Paraoxonase-1 (PON1) is specifically expressed in the liver and has crucial effects on various liver diseases. The functions and mechanisms underlying of PON1 in hepatocellular carcinoma (HCC) remain obscure. Here, we show that PON1 acts as a metabolic regulator to mitigate regulatory T (Treg) ce...

2025-09-07 | MTBLS12950 | MetaboLights
ProteomicsMass spectrometry analyzed human IL-33 interaction networks under various stimulations
C-terminal HA tagged hIL-33 were ectopically expressed in HEK293T cells for 24 hours, and demonstrated with indicating stimulations (Ctrl: without stimulations, Pap: 10ug/mL papain exposure for 30min, AS: 0.5mM arsenite exposure for 1hour). Cell lysates were collected for HA-immunoprecipitation and ...
ORGANISM(S): Homo Sapiens 
2022-04-26 | PXD033460 |
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