Sort   by:  
 Page size 
Transcriptomics16S rRNA gene sequence analysis of feces samples from rats treated with paclitaxel or vehicle controls
To address the role of gut microbiota in the development of paclitaxel-induced peripheral neuropathy (PIPN), we performed 16S rRNA sequencing analysis of feces samples at 14 days and 28 days after the initiation of paclitaxel or vehicle injections.
ORGANISM(S): Rattus norvegicus 
2023-10-16 | E-MTAB-13426 | biostudies-arrayexpress
TranscriptomicsRNA-Seq of rat dorsal root ganglions treated with paclitaxel against untreated controls
L4-L5 segment dorsal root ganglion (DRG) samples from controls and the paclitaxel-induced peripheral neuropathy (PIPN) rats were collected at day 14 after the initiation of paclitaxel treatment. Paclitaxel and vehicle were administered intraperitoneally at 2 mg/kg for four consecutive days at a fina...
ORGANISM(S): Rattus norvegicus 
2023-10-16 | E-MTAB-13430 | biostudies-arrayexpress
Transcriptomics16S rRNA gene sequence analysis of feces samples from 60 breast cancer patients treated with paclitaxel and 20 healthy controls
We randomly selected 60 patients who completed paclitaxel treatment for high-throughput sequencing. Grade 2 or higher (grade 2+) neuropathy has been defined as high-PIPN and Grade 1 as low-PIPN according to the National Cancer Institute Common Toxicity Criteria for Adverse Events (NCI-CTCAE version ...
ORGANISM(S): Homo sapiens 
2023-10-12 | E-MTAB-13423 | biostudies-arrayexpress
ProteomicsElevated N-glycosylation of Membrane Proteins Contributes to the Cisplatin Resistance of Non-small-cell Lung Cancer Cells
Chemoresistance remains to be the major restriction on the clinical use of cisplatin. Aberrant changes in protein glycosylation are closely associated with the growth, invasion, metastasis, and resistance to chemotherapy of cancer cells. Comprehensive study on the role of protein glycosylation in th...
ORGANISM(S): Homo Sapiens 
PXD028691 |
MetabolomicsThe telomere-to-telomere (T2T) genome of Peucedanum praeruptorum Dunn provides insights into the genome evolution and coumarin biosynthesis

BACKGROUND: Traditional Chinese medicine has used Peucedanum praeruptorum Dunn (Apiaceae) for a long time. Various coumarins, including the significant root constituents Praeruptorin (A-E), are the active constituents of the dried roots of P. praeruptorum. Previous trans...

2024-04-02 | MTBLS8679 | MetaboLights
Proteomicsproteomic analysis of mPGES-2 on NAFLD
Proteomic analysis was performed using LC-MS/MS technology from Shanghai Aiao Biotechnology Co., Ltd.. The abundance of peptide fractions in the livers of Ptges2+/+ (WT) HFD and Ptges2-/- (KO) HFD groups was quantified using unlabeled quantitative methods and differentially expressed proteins in eac...
ORGANISM(S): Mus Musculus 
PXD035389 |
ProteomicsMultiregional profiling of the brain transmembrane proteome uncovers novel regulators of depression
Our study provides an enabling technology and rich data resources to expand the understanding of transmembrane proteome organization and dynamics in the brain as well as accelerate the discovery of potential therapeutic targets for depression treatment.
ORGANISM(S): Mus Musculus 
PXD027559 |
ProteomicsCharacterization of kidney-specific and site-specific N-glycosylation signatures of isolated uromodulin from human urine
Uromodulin (Umod, Tamm–Horsfall protein), as the most abundant urinary N-glycoprotein exclusively produced by the kidney, can form filaments to antagonize the adhesion of uropathogens. However, the kidney-specific and site-specific N-glycosylation signatures of this glycoprotein remain poorly unders...
ORGANISM(S): Homo Sapiens 
PXD041640 |
Sort   by:  
 Page size