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TranscriptomicsLymphocyte gene expression data from moderate stage HD patients and controls
Highly quantitative biomarkers of neurodegenerative disease remain an important need in the urgent quest for disease modifying therapies. For Huntington's disease (HD), a genetic test is available (trait marker), but necessary state markers are still in development. In this report, we describe a lar...
ORGANISM(S): Homo sapiens 
2007-08-15 | E-GEOD-8762 | biostudies-arrayexpress
MetabolomicsFlavonoid Biosynthesis Is Likely More Susceptible to Elevation and Tree Age Than Other Branch Pathways Involved in Phenylpropanoid Biosynthesis in Ginkgo Leaves
Ginkgo leaves are always resources for flavonoids pharmaceutical industry. However, the effect of the elevation and tree age changes on flavonoid biosynthesis have not been detailly explored in Ginkgo leaves. In addition, whether these environmental pressures have similar effects on the biosynthesis...
2020-12-14 | MTBLS962 | MetaboLights
TranscriptomicsTranscription profiling of human normal melanocytes and melamoma cell lines reveal defective cell cycle checkpoint functions in melanoma are associated with altered patterns of gene expression
Defects in DNA damage responses may underlie genetic instability and malignant progression in melanoma. Cultures of normal human melanocytes (NHMs) and melanoma lines were analyzed to determine whether global patterns of gene expression could predict the efficacy of DNA damage cell cycle checkpoints...
ORGANISM(S): Homo sapiens 
2008-06-15 | E-GEOD-7469 | biostudies-arrayexpress
MetabolomicsDiagnostic Potential of Plasma IgG N-glycans in Discriminating Thyroid Cancer from Benign Thyroid Nodules and Healthy Controls

BACKGROUND: Novel biomarkers are urgently needed to distinguish between benign and malignant thyroid nodules and detect thyroid cancer in the early stage. The associations between serum IgG N-glycosylation and thyroid cancer risk have been revealed. We aimed to explore the potent...

2021-09-01 | MTBLS2935 | MetaboLights
UnknownStructural aspects of M₃ muscarinic acetylcholine receptor dimer formation and activation.
Not available
S-EPMC3290441 | biostudies-literature
TranscriptomicsTranscriptome of the demosponge Amphimedon queenslandica at life cycle transitions
Poriferans, like the demosponge Amphimedon queenslandica, are the earliest diverging metazoans and may hold the key to understanding the evolution of metazoan pathways. A. queenslandica exhibits a biphasic lifecycle, with free-swimming larvae and sessile adult stages. To study changes in the transcr...
ORGANISM(S): Amphimedon queenslandica 
2012-07-10 | E-GEOD-29978 | biostudies-arrayexpress
UnknownSoil moisture decline in China's monsoon loess critical zone: More a result of land-use conversion than climate change.
Not available
S-EPMC11009674 | biostudies-literature
TranscriptomicspsiCLIP of SmB, Prp16 and Prp22 in C, C* and P spliceosomal complexes
Despite the major progress made into spliceosome mechanisms through CryoEM, a major obstacle of this approach is its inability to map the positioning of helicases on the RNA substrate. Here we present a method ‘psiCLIP’ which probes protein-RNA interactions in specific spliceosomal states. The metho...
ORGANISM(S): Saccharomyces cerevisiae 
2020-03-15 | E-MTAB-8895 | biostudies-arrayexpress
MetabolomicsUPLC-Q-TOF/MS-Based Plasma and Urine Metabolomics Contribute to the Diagnosis of Sepsis
In this study, we aimed to identify potential metabolic biomarkers that can improve the diagnostic accuracy of sepsis. Sixty-six patients including 30 septic and 36 nonsepsis patients from an intensive care unit were recruited. The global plasma and urine metabolomic profiles were determined by ultr...
2023-04-18 | MTBLS3505 | MetaboLights
UnknownGibberellin-Induced Transcription Factor SmMYB71 Negatively Regulates Salvianolic Acid Biosynthesis in Salvia miltiorrhiza.
Not available
S-EPMC11679863 | biostudies-literature
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