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MetabolomicsHost specific sphingomyelin is critical for replication of diverse RNA viruses
Lipids and lipid metabolism play an important role in RNA virus replication, which typically occurs on host cell endomembrane structures in the cytoplasm through mechanisms that are not yet fully identified. We conducted genome-scale CRISPR screening and identified sphingomyelin synthase 1 (SMS1; en...
2026-10-29 | MTBLS11308 | MetaboLights
UnknownDe novo transcriptome and phytochemical analyses reveal differentially expressed genes and characteristic secondary metabolites in the original oolong tea (Camellia sinensis) cultivar 'Tieguanyin' compared with cultivar 'Benshan'.
Not available
S-EPMC6446291 | biostudies-literature
UnknownIn situ measurement of some soil properties in paddy soil using visible and near-infrared spectroscopy.
Not available
S-EPMC4143279 | biostudies-literature
UnknownIdentification of target genes of Astragalus mongholicus and Saposhnikovia divaricata extracts in human synoviocytes for potential osteoarthritis treatment.
Not available
S-EPMC12506284 | biostudies-literature
TranscriptomicsALS-causative mutations in FUS/TLS confer gain- and loss-of-function by altered association with SMN and U1-snRNP
The RNA-binding protein FUS/TLS, mutation in which is causative of the fatal motor neuron disease ALS, is demonstrated to directly bind to the U1-snRNP and SMN complexes. ALS-causative mutations in FUS/TLS are shown to abnormally enhance their interaction with SMN and reduce interaction with U1-snRN...
ORGANISM(S): Homo sapiens 
2015-02-10 | E-GEOD-64078 | biostudies-arrayexpress
ProteomicsThe identification and analysis of sORF and SEPs in Deinococcus radiodurans
The identification and analysis of sORF and SEPs in Deinococcus radiodurans
ORGANISM(S): Deinococcus Radiodurans R1 
2022-09-23 | PXD033880 |
MetabolomicsVGLL4 modulates Paneth cells and sustains intestinal homeostasis.
Paneth cells are defensive cells in the intestinal tract, which secrete niche factors and antimicrobial peptides (AMPs) to maintain the small intestinal stem cell niche and immune homeostasis. Here, we show that Vestigial-like family member 4 (VGLL4) plays a pivotal role in maintaining small intesti...
2026-03-12 | MTBLS10456 | MetaboLights
ProteomicsAmelioration of nonalcoholic fatty liver disease by inhibiting the deubiquitylating enzyme RPN11
Nonalcoholic fatty liver disease (NAFLD) including its more severe manifestation, nonalcoholic steatohepatitis (NASH), is a global public health challenge. Here, we reveal a role for the deubiquitinating enzyme RPN11 in the development of NAFLD and NASH. Ablation of hepatic RPN11 markedly protected ...
ORGANISM(S): Homo Sapiens Mus Musculus 
2024-06-15 | PXD053163 |
ProteomicsLC-MS/MS proteomic analysis of candidate BATF2-binding proteins
Label-free Liquid Chromatography-Mass Spectrometry/Mass Spectrometry (LC-MS/MS) proteomic analysis of candidate BATF2-binding proteins
ORGANISM(S): Homo Sapiens 
2022-10-27 | PXD037788 |
ProteomicsLenalidomide-induced pure red cell aplasia analysis
The RVd therapy, combining lenalidomide, bortezomib, and dexamethasone, is a mainstay treatment for multiple myeloma. A multiple myeloma patient developed pure red cell aplasia (PRCA) following RVd treatment, despite the absence of common PRCA triggers. In vitro analyses revealed lenalidomide as a p...
ORGANISM(S): Homo Sapiens 
2024-09-03 | PXD055495 |
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