Excessive renal fibrosis is a common pathology in progressive chronic kidney diseases. Inflammatory injury and aberrant repair processes contribute to the development of kidney fibrosis. Myeloid cells, particularly monocytes/macrophages, play a crucial role in kidney fibrosis by releasing their proi...
In order to study the function of CHR729 in rice, the T-DNA insertion mutant of CHR729 was obtained and analysed. Total RNAs were extracted from 11-day-old seedlings of both wild type (Hwayoung) and CHR729 mutant plants. Affymetrix GeneChip® Rice Genome Array hybridization was performed with three b...
We report the application of CHIP-seq technology for high-throughput profiling of histone modifications in HY(Hwayong) and chd1(chr729). By obtaining about 12 million reads of sequence from chromatin immunoprecipitated DNA, we generated genome-wide H3K4me3 and H3k27me3 maps of HY(Hwayong) and chd1(c...
Renal fibrosis, a hallmark of chronic kidney diseases, is driven by the activation of renal fibroblasts. Recent studies have highlighted the role of glycolysis in this process. Nevertheless, one critical glycolytic activator, 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 (PFKFB3), remain...
The testicular tissue of Wanxi white geese was selected from three stages of the laying cycle (initial, peak and end stages), and the DIA strategy was used for proteomic sequencing.
The testicular tissue of Hungarian White Goose was selected from three stages of the laying cycle (initial, peak and end stages), and the DIA strategy was used for proteomic sequencing.
In patients with hepatocellular carcinoma (HCC) meeting the Milan criteria, liver transplantation (LT) is an effective therapy. This study aims to define the survival-related molecular biological features helping precisely identifying the patients with HCC beyond the Milan criteria who have acceptab...
