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TranscriptomicsLoss of MeCP2 function is associated with distinct gene expression changes in the striatum
Rett syndrome (RTT) is a neurodevelopmental disorder characterized by developmental regression around 6-18 months after birth, followed by a lifetime of intellectual disability, stereotyped behaviors, and motor deficits. RTT is caused by mutations in MeCP2, a methyl-CpG binding protein that was trad...
ORGANISM(S): Mus musculus 
2013-07-13 | E-GEOD-42895 | biostudies-arrayexpress
UnknownThe Crucial Role of DNA Methylation and MeCP2 in Neuronal Function.
Not available
S-EPMC5448015 | biostudies-literature
UnknownNeuronal Yin Yang1 in the prefrontal cortex regulates transcriptional and behavioral responses to chronic stress in mice.
Not available
S-EPMC8748737 | biostudies-literature
UnknownIndependent genetic strategies define the scope and limits of CDKL5 deficiency disorder reversal.
Not available
S-EPMC11866500 | biostudies-literature
UnknownX-linked cellular mosaicism underlies age-dependent occurrence of seizure-like events in mouse models of CDKL5 deficiency disorder.
Not available
S-EPMC7856307 | biostudies-literature
GenomicsGenome-wide activity-dependent MeCP2 phosphorylation regulates nervous system development and function [ChIP-Seq]
Autism spectrum disorders such as Rett syndrome (RTT) have been hypothesized to arise from defects in experience-dependent synapse maturation. RTT is caused by mutations in MECP2, a nuclear protein that becomes phosphorylated at S421 in response to neuronal activation. We show here that disruption o...
ORGANISM(S): Mus musculus 
2011-09-08 | E-GEOD-31951 | biostudies-arrayexpress
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