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UnknownSite-directed mutagenesis of bifunctional riboflavin kinase/FMN adenylyltransferase via CRISPR/Cas9 to enhance riboflavin production.
Vitamin B2 is an essential water-soluble vitamin. For most prokaryotes, a bifunctional enzyme called FAD synthase catalyzes the successive conversion of riboflavin to FMN and FAD. In this study, the plasmid pNEW-AZ containing six key genes for the riboflavin synthesis was transformed into...
S-EPMC11047187 | biostudies-literature
UnknownLumbar region perception segmentation: a novel algorithm for automated vertebral motion parameter measurement.

Background

Lower back pain frequently results from irregular lumbar spine movement. Quantifying vertebral motion is crucial for diagnosing lumbar spine disorders, but the accuracy and efficiency of traditional methods are limited. To address this limitation and automate the measurement of ve...
S-EPMC12514737 | biostudies-literature
UnknownHigh-viscosity injector-based pink-beam serial crystallography of microcrystals at a synchrotron radiation source.
Since the first successful serial crystallography (SX) experiment at a synchrotron radiation source, the popularity of this approach has continued to grow showing that third-generation synchrotrons can be viable alternatives to scarce X-ray free-electron laser sources. Synchrotron radiation flux may...
S-EPMC6503920 | biostudies-literature
UnknownA novel prostate cancer susceptibility locus at 19q13.
A two-stage genome-wide association study (GWAS) of the Cancer Genetic Markers of Susceptibility (CGEMS) initiative identified single nucleotide polymorphisms (SNP) in 150 regions across the genome that may be associated with prostate cancer (PCa) risk. We filtered these results to identify 43 indep...
S-EPMC2803342 | biostudies-literature
UnknownUnexpected slowdown of US pollutant emission reduction in the past decade.
Ground and satellite observations show that air pollution regulations in the United States (US) have resulted in substantial reductions in emissions and corresponding improvements in air quality over the last several decades. However, large uncertainties remain in evaluating how recent regulations a...
S-EPMC5960319 | biostudies-literature
UnknownTwo independent prostate cancer risk-associated Loci at 11q13.
Single nucleotide polymorphisms (SNP) at 11q13 were recently implicated in prostate cancer risk by two genome-wide association studies and were consistently replicated in multiple study populations. To explore prostate cancer association in the regions flanking these SNPs, we genotyped 31 tagging SN...
S-EPMC2802212 | biostudies-literature
UnknownHemizygous variants in protein phosphatase 1 regulatory subunit 3F (PPP1R3F) are associated with a neurodevelopmental disorder characterized by developmental delay, intellectual disability and autistic features.
Protein phosphatase 1 regulatory subunit 3F (PPP1R3F) is a member of the glycogen targeting subunits (GTSs), which belong to the large group of regulatory subunits of protein phosphatase 1 (PP1), a major eukaryotic serine/threonine protein phosphatase that regulates diverse cellular processes. Here,...
S-EPMC10549786 | biostudies-literature
UnknownEvidence for two independent prostate cancer risk-associated loci in the HNF1B gene at 17q12.
We carried out a fine-mapping study in the HNF1B gene at 17q12 in two study populations and identified a second locus associated with prostate cancer risk, approximately 26 kb centromeric to the first known locus (rs4430796); these loci are separated by a recombination hot spot. We confirmed the ass...
S-EPMC3188432 | biostudies-literature
UnknownDiscovery of 318 new risk loci for type 2 diabetes and related vascular outcomes among 1.4 million participants in a multi-ancestry meta-analysis.
We investigated type 2 diabetes (T2D) genetic susceptibility via multi-ancestry meta-analysis of 228,499 cases and 1,178,783 controls in the Million Veteran Program (MVP), DIAMANTE, Biobank Japan and other studies. We report 568 associations, including 286 autosomal, 7 X-chromosomal and 25 identifie...
S-EPMC7343592 | biostudies-literature
UnknownSequence variants at 22q13 are associated with prostate cancer risk.
To search for genetic variants that are associated with prostate cancer risk in the genome, we combined the data from our genome-wide association study (GWAS) in a population-based case-control study in Sweden with publicly available GWAS data from the Cancer Genetic Markers of Susceptibility (CGEMS...
S-EPMC2705898 | biostudies-literature
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