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MetabolomicsATG9A-PLA2G6 axis reprograms phospholipid metabolism to drive metabolic liver disease and hepatocellular carcinoma

The liver orchestrates systemic metabolism, and its dysfunction drives diseases including metabolic dysfunction-associated steatotic liver disease (MASLD) and hepatocellular carcinoma (HCC). ATG9A, an autophagy-related transmembrane protein and lipid scramblase, regulates lipid dynamics, yet its ...

2025-10-24 | MTBLS12451 | MetaboLights
ProteomicsA G-protein-coupled receptor modulates gametogenesis via PKG-mediated signaling cascade in Plasmodium berghei
Gametogenesis is essential for malaria parasite transmission, but the molecular mechanism of this process remains to be refined. Here, we identified a G-protein-coupled receptor 180 (GPR180) that plays a critical role in signal transduction during gametogenesis in Plasmodium. In the rodent parasite ...
ORGANISM(S): Plasmodium berghei ANKA 
2022-04-01 | PXD030837 | Pride
Gametogenesis G-protein-coupled receptors Cgmp-pkg- ca2+ signaling cascades Malaria 
TranscriptomicsA crucial role of the zinc finger protein PfZnFP-G in sexual differentiation of the malaria parasites, Plasmodium falciparum
We described the biological role of a putative zinc finger protein (Plasmodb id: PF3D7_1008600), which plays an important role during the initiation and subsequent progression of gametocytogenesis in P. falciparum. Hence we termed the protein P. falciparum Zinc Finger Protein for Gametocytogenesis (...
ORGANISM(S): Plasmodium falciparum 
2015-11-24 | E-GEOD-75295 | biostudies-arrayexpress
MetabolomicsMechanism of interventional effect and targets of Zhuyu Pill in regulating and suppressing colitis and cholestasis

Zhuyu pill (ZYP) is a traditional Chinese medicine prescription composed of two drugs, Coptis chinensis Franch. and Tetradium ruticarpum (A. Jussieu) T. G. Hartley, and is commonly used in the clinical treatment of diseases of the digestive system. However, the mechanism underly...

2022-11-02 | MTBLS4980 | MetaboLights
UnknownSpecific recognition and stabilization of monomeric and multimeric G-quadruplexes by cationic porphyrin TMPipEOPP under molecular crowding conditions.
Not available
S-EPMC3627595 | biostudies-literature
TranscriptomicsP. falciparum (lab strain DD2) treated with ionomycin vs untreated [CGH]
Calcium is a universal second messenger molecule which plays a significant role in several biological processes. Presence of calcium sensors (calmodulins) and calcium-dependent protein kinases in Plasmodium species suggests an important role of calcium-dependent signaling pathways in the regulation ...
ORGANISM(S): Plasmodium falciparum 
2012-07-14 | E-GEOD-33605 | biostudies-arrayexpress
TranscriptomicsP. falciparum (lab strain DD2) treated with A23187 vs untreated [CGH]
Calcium is a universal second messenger molecule which plays a significant role in several biological processes. Presence of calcium sensors (calmodulins) and calcium-dependent protein kinases in Plasmodium species suggests an important role of calcium-dependent signaling pathways in the regulation ...
ORGANISM(S): Plasmodium falciparum 
2012-07-14 | E-GEOD-33764 | biostudies-arrayexpress
UnknownNovel malformations: Chiari type 1 and hydrocephalus in Zhu-Tokita-Takenouchi-Kim syndrome and novel SON variants.
Not available
S-EPMC9755635 | biostudies-literature
UnknownTwo cationic porphyrin isomers showing different multimeric G-quadruplex recognition specificity against monomeric G-quadruplexes.
Not available
S-EPMC4117758 | biostudies-literature
ProteomicsSelenite metabolism and reduction in Ganoderma lucidum
G. lucidum could reduce selenite to element Se and further aggregated into selenium nanoparticles (SeNPs), simultaneously accompanying by the production of pungent odorous volatile selenium metabolites. iTRAQ-based quantitative proteomic analysis revealed the abundance of proteins involved in sele...
ORGANISM(S): Ganoderma Lucidum G.260125-1 
2022-08-03 | PXD035786 |
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