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Transcriptomicsextracellular calcium chelation experiment_P. falciparum (lab strain 3d7) schizonts treated with ionomycin vs P. falciparum (lab strain 3d7) reference RNA pool
Calcium is a universal second messenger molecule which plays a significant role in several biological processes. Presence of calcium sensors (calmodulins) and calcium-dependent protein kinases in Plasmodium species suggests an important role of calcium-dependent signaling pathways in the regulation ...
ORGANISM(S): Plasmodium falciparum 3D7 
2012-07-14 | E-GEOD-33835 | biostudies-arrayexpress
Transcriptomicsextracellular calcium chelation experiment_P. falciparum (lab strain 3d7) schizonts treated with EGTA and ionomycin vs P. falciparum (lab strain 3d7) reference RNA pool
Calcium is a universal second messenger molecule which plays a significant role in several biological processes. Presence of calcium sensors (calmodulins) and calcium-dependent protein kinases in Plasmodium species suggests an important role of calcium-dependent signaling pathways in the regulation ...
ORGANISM(S): Plasmodium falciparum 3D7 
2012-07-14 | E-GEOD-33836 | biostudies-arrayexpress
TranscriptomicsP. falciparum (lab strain 3d7) schizonts treated with A23187 vs P. falciparum (lab strain 3d7) reference RNA pool
Calcium is a universal second messenger molecule which plays a significant role in several biological processes. Presence of calcium sensors (calmodulins) and calcium-dependent protein kinases in Plasmodium species suggests an important role of calcium-dependent signaling pathways in the regulation ...
ORGANISM(S): Plasmodium falciparum 3D7 
2012-07-14 | E-GEOD-33797 | biostudies-arrayexpress
TranscriptomicsP. falciparum (lab strain 3d7) schizonts treated with ionomycin vs P. falciparum (lab strain 3d7) reference RNA pool
Calcium is a universal second messenger molecule which plays a significant role in several biological processes. Presence of calcium sensors (calmodulins) and calcium-dependent protein kinases in Plasmodium species suggests an important role of calcium-dependent signaling pathways in the regulation ...
ORGANISM(S): Plasmodium falciparum 3D7 
2012-07-14 | E-GEOD-33796 | biostudies-arrayexpress
TranscriptomicsP. falciparum (lab strain 3d7) schizonts untreated control vs P. falciparum (lab strain 3d7) reference RNA pool
Calcium is a universal second messenger molecule which plays a significant role in several biological processes. Presence of calcium sensors (calmodulins) and calcium-dependent protein kinases in Plasmodium species suggests an important role of calcium-dependent signaling pathways in the regulation ...
ORGANISM(S): Plasmodium falciparum 3D7 
2012-07-14 | E-GEOD-33795 | biostudies-arrayexpress
Transcriptomicsextracellular calcium chelation experiment_P. falciparum (lab strain 3d7) schizonts untreated vs P. falciparum (lab strain 3d7) reference RNA pool
Calcium is a universal second messenger molecule which plays a significant role in several biological processes. Presence of calcium sensors (calmodulins) and calcium-dependent protein kinases in Plasmodium species suggests an important role of calcium-dependent signaling pathways in the regulation ...
ORGANISM(S): Plasmodium falciparum 3D7 
2012-07-14 | E-GEOD-33834 | biostudies-arrayexpress
ProteomicsMilk glycopeptide across lactation
Protein N-glycosylation is an essential post-translational modification (PTM) frequently occurring on human milk proteins. These PTMs assist in protecting the infant's health and function amongst others as competitive inhibitors of pathogen binding and immunomodulators. Due to the individual unique...
ORGANISM(S): Homo Sapiens 
2020-11-07 | PXD022415 | panorama
TranscriptomicsTranscriptional profiling of growth perturbations of the human malaria parasite Plasmodium falciparum
The microarray experiments were carried out using a long oligonucleotide DNA microarray that represent all 5363 P. falciparum genes with one oligonucleotide per 1.9kb of coding sequence on average (Hu et al. 2007). Total 247 microarray experiments were carried out including 29-drug treatment time co...
ORGANISM(S): Plasmodium falciparum 
2010-05-18 | E-GEOD-19468 | biostudies-arrayexpress
TranscriptomicsIdentification of a New Chemical Class of Antimalarials, ACT-213615
The increasing spread of drug-resistant malaria strains underscores the need for new antimalarial agents with novel modes of action (MOAs). Here, we describe a compound representative of a new class of antimalarials. This molecule, ACT-213615, potently inhibits in vitro erythrocytic growth of all te...
ORGANISM(S): Plasmodium falciparum 
2012-07-19 | E-GEOD-39485 | biostudies-arrayexpress
TranscriptomicsQuantitative time-course profiling of Plasmodium falciparum transcripts and proteins throughout the 48-hour intraerythrocytic developmental cycle
Quantitative studies of the P. falciparum transcriptome have shown that the tightly controlled progression of the parasite through the intraerythrocytic developmental cycle (IDC) is accompanied by a continuous gene expression cascade where most expressed genes exhibit a single transcriptional peak. ...
ORGANISM(S): Plasmodium falciparum 
2011-06-07 | E-GEOD-24416 | biostudies-arrayexpress
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