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TranscriptomicsTranscription profiling of human T98G cells during cell cycle in T98G
The mammalian Retinoblastoma (RB) family including pRB, p107, and p130 represses E2F target genes through mechanisms that are not fully understood. In D. melanogaster, RB-dependent repression is mediated in part by the multisubunit protein complex Drosophila RBF, E2F, and Myb (dREAM) that contains h...
ORGANISM(S): Homo sapiens 
2008-06-16 | E-GEOD-8537 | biostudies-arrayexpress
TranscriptomicsUndifferentiated pleomorphic sarcoma recapitulates the expressional profile of Subtype II Leiomyosarcoma
Background: Undifferentiated pleomorphic sarcoma (UPS), used to be called malignant fibrous histiocytoma (MFH), is a malignant soft tissue tumor of uncertain origin, and is characterized by morphology. UPS often share similar morphological characters with other sarcomas, especially Leiomyosarcoma. ...
ORGANISM(S): Homo sapiens 
2015-05-19 | E-GEOD-53844 | biostudies-arrayexpress
TranscriptomicsDifferent molecular pathways along with pathogenesis of three subtypes of Leiomyosarcoma
Leiomyosarcoma (LMS) is a malignant neoplasm of smooth muscle and is an aggressive soft tissue tumor, have complex genetic abnormalities and could be defined as three molecular subtypes. Since that the molecular heterogeneity of LMS, the pathogenesis analysis per subtype will be highly necessary and...
ORGANISM(S): Homo sapiens 
2015-05-19 | E-GEOD-54511 | biostudies-arrayexpress
TranscriptomicsStratification of Leiomyosarcoma molecular subtypes by 3' end RNA-sequencing: Toward precision medicine
Leiomyosarcoma (LMS) is a malignant neoplasm with smooth muscle differentiation. Little is known about its molecular heterogeneity and no targeted therapy currently exists for LMS. We demonstrate the existence of 3 molecular subtypes in a cohort of 99 cases and an independent cohort of 82 LMS. Tw...
ORGANISM(S): Homo sapiens 
2015-05-19 | E-GEOD-45510 | biostudies-arrayexpress
TranscriptomicsTwo New Stromal Signatures Stratify Breast Cancers with Different Prognosis
Purpose: Multiple studies from last decades have shown that the microenvironment of carcinomas plays an important role in the initiation, progression and metastasis of cancer. Our group has previously identified novel cancer stroma gene expression signatures associated with outcome differences in ...
ORGANISM(S): Homo sapiens 
2013-11-21 | E-GEOD-42948 | biostudies-arrayexpress
TranscriptomicsA shared transcriptional program in early breast neoplasias despite genetic and clinical distinctions
The earliest recognizable stages of breast neoplasia are lesions that represent a heterogeneous collection of epithelial proliferations currently classified based on morphology. Their role in the development of breast cancer is not well understood but insight into the critical events at this early s...
ORGANISM(S): Homo sapiens 
2014-05-04 | E-GEOD-47462 | biostudies-arrayexpress
TranscriptomicsDistinct gene expression profiles between overt GIST and miniGIST
In contrast to the paucity of clinic GIST (Gastrointestinal stromal tumor; 0.0014 % happening rate), there is a more than twenty thousand times higher rate for miniGISTs, about ~30% of human population could be identified to have miniGISTs. Exploring the molecular differences between miniGISTs and o...
ORGANISM(S): Homo sapiens 
2014-12-25 | E-GEOD-52666 | biostudies-arrayexpress
UnknownA phase I trial of LXS196, a protein kinase C (PKC) inhibitor, for metastatic uveal melanoma.
Not available
S-EPMC10006169 | biostudies-literature
TranscriptomicsTranscriptional profiling of lncRNAs and novel transcribed regions across a diverse panel of archived human cancers
Molecular characterization of tumors has been critical for identifying important genes in cancer biology and for improving tumor classification and diagnosis. Long non-coding RNAs (lncRNAs), as a new, relatively unstudied class of transcripts, provide a rich opportunity to identify both functional d...
ORGANISM(S): Homo sapiens 
2012-08-24 | E-GEOD-28866 | biostudies-arrayexpress
UnknownConstruction of human activity-based phosphorylation networks.
Not available
S-EPMC3658267 | biostudies-literature
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