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TranscriptomicsA Chondrogenic Molecule that Repairs Cartilage by Transcriptional Regulation of CBF-beta
Osteoarthritis (OA) is a degenerative joint disease that involves destruction of articular cartilage and eventually leads to disability. Mesenchymal stem cells (MSCs) reside in healthy and diseased cartilage, and through their chondrogenic potential may provide a strategy for cartilage repair. To th...
ORGANISM(S): Homo sapiens 
2012-05-01 | E-GEOD-35546 | biostudies-arrayexpress
TranscriptomicsDifferential gene expression analysis comparing vehicle (DMSO) versus KHS101 in glioblastoma cells
To elucidate the anti tumour activity of the small molecule KHS101, in particular in patient-derived glioma stem-like cells.
ORGANISM(S): Homo sapiens 
2017-09-01 | E-MTAB-5713 | biostudies-arrayexpress
TranscriptomicsAn RNAi Screen Identifies TRRAP as a Regulator of Brain Tumor-Initiating Cell Differentiation
Glioblastoma multiforme is the most common and most aggressive type of primary brain tumor. The brain-infiltrative character of glioblastoma makes complete surgical removal of the tumor impossible and neither radiation nor current chemotherapy provide cure. Recent evidence shows that glioblastoma mu...
ORGANISM(S): Homo sapiens 
2011-03-14 | E-GEOD-27931 | biostudies-arrayexpress
TranscriptomicsA small molecule accelerates neuronal differentiation in the adult rat
Adult neurogenesis occurs in mammals and provides a mechanism for continuous neural plasticity in the brain.However, little is known about the molecular mechanisms regulating hippocampal neural progenitor cells (NPCs) and whether their fate can be pharmacologically modulated to improve neural plasti...
ORGANISM(S): Rattus norvegicus 
2010-08-18 | E-GEOD-23668 | biostudies-arrayexpress
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