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CD4+ helper T cells are critical for immunological response. Th2 cells, a subset of CD4+ helper T cells, are responsible for asthma and other immune diseases. We found a Th2 secreted protein, ExtraCellular Matrix protein 1 (ECM1), which is highly induced by classic IL-4 signaling pathway during help...
ORGANISM(S): Mus musculus 
Proximity labeling has revolutionized the study of dynamic subcellular proteomes by enabling the capture of transient protein interactions within living cells, yet the application of existing platforms to hard-to-transfect primary cells remains challenging. Here, we leverage a bioorthogonal proximit...
ORGANISM(S): Mus Musculus 
Hypoxia represents a major physiological challenge for prawns and is a problem in aquaculture. Therefore, an understanding of the metabolic response mechanism of economically important prawn species to hypoxia and re-oxygenation is essential. However, little is known about the intrinsic mechanisms b...
2021-05-17 | MTBLS584 | MetaboLights
For H1 PTM identification, HeLa cells were exposed to 10 Gy IR or not and released for 2 min. Histones were extracted and deamidated peptides were identified by mass spectrometry (MS). For CTPS1 phosphorylation sites identification, whole cell lysates were extracted, immunoprecipitated using anti-F...
ORGANISM(S): Homo sapiens (Human) 
2025-02-19 | PXD060714 | Pride
The crosstalk between the cartilage and subchondral bone plays a crucial role in the pathogenesis and progression of OA. The aim of this study was to identify soluble mediators released by osteoblasts that could induce the release of catabolic factors by chondrocytes. Global protein sequencing of su...
ORGANISM(S): Homo sapiens (Human) 
2025-05-06 | PXD021135 | Pride
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