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MetabolomicsLipid-accumulated reactive astrocytes promote disease progression in epilepsy (Human lipidomics)

Reactive astrocytes play an important role in neurological diseases, but their molecular and functional phenotypes in epilepsy are unclear. Here, we show that in patients with temporal lobe epilepsy (TLE) and mouse models of epilepsy, excessive lipid accumulation in astrocytes leads to the format...

2025-07-03 | MTBLS8856 | MetaboLights
MetabolomicsLipid-accumulated reactive astrocytes promote disease progression in epilepsy (Mice lipidomics)

Reactive astrocytes play an important role in neurological diseases, but their molecular and functional phenotypes in epilepsy are unclear. Here, we show that in patients with temporal lobe epilepsy (TLE) and mouse models of epilepsy, excessive lipid accumulation in astrocytes leads to the format...

2025-07-04 | MTBLS8865 | MetaboLights
ProteomicsHuman Plasma Proteome with Three-dimensional Strategies by Highresolution Quadrupole Orbitrap Mass Spectrometry
Five three-dimensional strategies combining HAP depletion (the 1st dimension) and protein fractionation (the 2nd dimension), followed by LC-MS/MS analysis (the 3rd dimension) were developed and compared for human plasma proteome profiling. Pros and cons of the five strategies are discussed for two i...
ORGANISM(S): Homo Sapiens 
2017-06-20 | PXD008441 |
MetabolomicsGNPS - LC-MS/MS metabolomes of fecal samples from zoo mammals
LC-MS/MS metabolomes of fecal samples from 101 individuals from 25 mammalian species, in collaboration with a zoo. DDA data for molecular networking. Collected on a qExactive and includes fecal samples, dietary samples, and quality control samples. See linked datasets: MSV000083859, https://www.ncbi...
ORGANISM(S): Mammalia (ncbitaxon:40674) 
MSV000086131 | GNPS
MetabolomicsGNPS - GC-MS metabolomes of fecal samples from zoo mammals
GC-MS single quad metabolomes of fecal samples from 101 individual animals from 25 mammalian species, in collaboration with a zoo. Includes fecal samples, dietary samples, and quality control samples. See linked datasets: MSV000086131, https://www.ncbi.nlm.nih.gov/bioproject/PRJNA693262/ Reference:...
ORGANISM(S): Mammalia (ncbitaxon:40674) 
2019-05-26 | MSV000083859 | GNPS
ProteomicsThe MS data for accuracy evaluation of absolute quantification algorithms
The DDA and DIA data for accuracy evaluation of absolute quantification algorithms.
ORGANISM(S): Mus Musculus Saccharomyces Cerevisiae 
2018-05-08 | PXD009719 |
ProteomicsThe MS data for precision evaluation of absolute quantification algorithms
Human embryonic kidney (HEK) cells 293 are analyzed by two state-of-the-art MS instruments (Thermo Orbitrap Fusion and Q Exactive HF) in quadruplicate for precision evaluation.
ORGANISM(S): Homo Sapiens 
2018-05-08 | PXD009720 |
ProteomicsInteraction protein of Ptc1::eGFP and Ptc2::eGFP in Aspergillus flavus
There are the Mass spectrum original data of Ptc1 and Ptc2. The immunoprecipitated proteins from Ptc1::eGFP and Ptc2::eGFP stains in Aspergillus flavus were detected with SDS-PAGE. Next, in-gel tryptic digestion, and the peptides were obtained and detected by liquid chromatog-raphy coupled with tan...
ORGANISM(S): Aspergillus Flavus Nrrl3357 
2023-07-06 | PXD038079 |
ProteomicsArtificial intelligence defines protein-based classification of thyroid nodules
We applied PCT-DIA on a total of 1161 nodules from 1133 patients using either tissue cores (1 mm diameter; 0.5–1 mm depth) punched from regions of interest marked on retrospective FFPE tissue blocks or prospective cytology specimens from FNA aspirates. The samples comprise (i) a discovery set of FFP...
ORGANISM(S): Homo Sapiens 
2022-09-07 | PXD036554 |
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