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ProteomicsEnergy-translation coupling limits yeast anaerobic growth
This study employs yeast as a model system to thoroughly investigate the differences in regulatory mechanisms under various nutrient limitation conditions, utilizing a systems biology approach integrated with techniques such as multi-omics analysis.To obtain a comprehensive quantitative landscape of...
ORGANISM(S): Staphylococcus Aureus 
PXD078963 |
ProteomicsStress-Induced Premature Senescence in High Five Cell Cultures: A Principal Factor in Cell-Density Effects
The Baculovirus Expression Vector System (BEVS) is highly valued in vaccine development, protein engineering, and drug metabolism research due to its biosafety, operational convenience, rapid scalability, and capacity for self-assembling virus-like particles. However, increasing cell density at the ...
ORGANISM(S): Trichoplusia Ni 
2024-10-31 | PXD057379 |
ProteomicsOverexpression of SLC2A1, ALDOC and PFKFB4 in the glycolysis pathway drives strong drug resistance in 3D HeLa tumor cell spheroids
The three-dimensional (3D) tumor spheroid model exhibits enhanced fidelity in replicating the tumor microenvironment and demonstrates exceptional resistance to clinical drugs compared to the two-dimensional (2D) monolayer model. In this study, we used multi-omics (transcriptome, proteomics, and me...
ORGANISM(S): Homo Sapiens 
PXD053058 |
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