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To gain insight into FTO function, we knocked down and overexpressed FTO in HEK293 cells.Genetrail analyses of expression profiles pointed to the RNA splicing and processing machinery. Intriguingly, using immunocytochemistry and confocal laser scanning microscopy, we observed strong enrichment of FT...
ORGANISM(S): Homo sapiens 
Background The heterogeneity of sepsis represents a major problem for the development of personalized sepsis therapies. Thus, sepsis subtyping emerged as an important tool to approach this problem, but little progress was made due to insufficient molecular insights. Modern proteomics techniques allo...
ORGANISM(S): Homo sapiens (Human) 
2025-09-04 | PXD064125 | Pride
Background: Sepsis therapy is still limited to the treatment of the underlying infection and supportive measures. Therapeutic options that address the molecular changes of sepsis have not yet been identified. With the aim of a future individualized therapy, we used unsupervised machine learning (ML)...
ORGANISM(S): Homo sapiens (Human) 
2025-12-08 | PXD058562 | Pride
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