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TranscriptomicsVascular histone deacetylation by pharmacological HDAC inhibition [TSA, RNA-seq]
HDAC inhibitors are thought to regulate gene expression by post-translational modification of histone as well as non-histone proteins. Often studied at single loci, increased histone acetylation is the paradigmatic mechanism of action, however, little is known of the extent of genome-wide changes of...
ORGANISM(S): Homo sapiens 
2014-02-23 | E-GEOD-37376 | biostudies-arrayexpress
TranscriptomicsVascular histone deacetylation by pharmacological HDAC inhibition [SAHA, RNA-seq]
HDAC inhibitors are thought to regulate gene expression by post-translational modification of histone as well as non-histone proteins. Often studied at single loci, increased histone acetylation is the paradigmatic mechanism of action, however, little is known of the extent of genome-wide changes of...
ORGANISM(S): Homo sapiens 
2014-02-23 | E-GEOD-54912 | biostudies-arrayexpress
GenomicsGenome-wide analysis distinguishes hyperglycemia regulated epigenetic signatures of primary vascular cells (ChIP-seq)
We report that hyperglycemia-mediated induction of genes and pathways associated to endothelial dysfunction occur through modulation of acetylated H3K9/K14 inversely correlated with methyl-CpG content. Examination of H3K9/K14 histone acetylation and DNA methylation in hyperglycemic conditions.
ORGANISM(S): Homo sapiens 
2011-06-01 | E-GEOD-29251 | biostudies-arrayexpress
TranscriptomicsEtiology matters - Comparing Genomic DNA Methylation Patterns in Three Rat Models of Acquired Epilepsy (Amygdala stimulation – mRNA-seq)
Explore DNA methylation in focal amygdala stimulation model of epilepsy and its relationship to gene expression. Examination of expression changes in stimulated rats compared to sham operated animals in focal amygdala stimulation model of epilpesy.
ORGANISM(S): Rattus norvegicus 
2016-09-06 | E-GEOD-75402 | biostudies-arrayexpress
GenomicsVascular histone deacetylation by pharmacological HDAC inhibition [TSA, ChIP-seq]
HDAC inhibitors are thought to regulate gene expression by post-translational modification of histone as well as non-histone proteins. Often studied at single loci, increased histone acetylation is the paradigmatic mechanism of action, however, little is known of the extent of genome-wide changes of...
ORGANISM(S): Homo sapiens 
2014-02-23 | E-GEOD-37377 | biostudies-arrayexpress
GenomicsVascular histone deacetylation by pharmacological HDAC inhibition [TSA, MBD-seq]
HDAC inhibitors are thought to regulate gene expression by post-translational modification of histone as well as non-histone proteins. Often studied at single loci, increased histone acetylation is the paradigmatic mechanism of action, however, little is known of the extent of genome-wide changes of...
ORGANISM(S): Homo sapiens 
2014-02-23 | E-GEOD-54911 | biostudies-arrayexpress
GenomicsVascular histone deacetylation by pharmacological HDAC inhibition [TSA, mouse, ChIP-seq]
HDAC inhibitors are thought to regulate gene expression by post-translational modification of histone as well as non-histone proteins. Often studied at single loci, increased histone acetylation is the paradigmatic mechanism of action, however, little is known of the extent of genome-wide changes of...
ORGANISM(S): Mus musculus 
2014-02-23 | E-GEOD-54910 | biostudies-arrayexpress
TranscriptomicsEtiology matters - Comparing Genomic DNA Methylation Patterns in Three Rat Models of Acquired Epilepsy (TBI – mRNA-seq)
Explore DNA methylation in traumatic brain injury model of epilepsy and its relationship to gene expression. Examination of expression changes in stimulated rats compared to sham operated animals in traumatic brain injury model of epilepsy.
ORGANISM(S): Rattus norvegicus 
2016-09-06 | E-GEOD-75120 | biostudies-arrayexpress
GenomicsVascular histone deacetylation by pharmacological HDAC inhibition
This SuperSeries is composed of the SubSeries listed below. HDAC inhibitors are thought to regulate gene expression by post-translational modification of histone as well as non-histone proteins. Often studied at single loci, increased histone acetylation is the paradigmatic mechanism of action, how...
ORGANISM(S): Mus musculus 
2014-02-23 | E-GEOD-37378 | biostudies-arrayexpress
GenomicsVascular histone deacetylation by pharmacological HDAC inhibition [SAHA, ChIP-seq]
HDAC inhibitors are thought to regulate gene expression by post-translational modification of histone as well as non-histone proteins. Often studied at single loci, increased histone acetylation is the paradigmatic mechanism of action, however, little is known of the extent of genome-wide changes of...
ORGANISM(S): Homo sapiens 
2014-02-23 | E-GEOD-54909 | biostudies-arrayexpress
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