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ProteomicsReactive astrocytes in ALS display dysregulated intron retention
Reactive astrocytes are implicated in amyotrophic lateral sclerosis (ALS), although the mechanisms controlling reactive transformation are unknown. We show that decreased intron retention (IR) is common to human iPSC-derived astrocytes carrying VCP, C9orf72 and SOD1 ALS-causing mutations as well as ...
ORGANISM(S): Homo sapiens (Human) 
2021-09-09 | PXD022604 | Pride
Alternative splicing Astrocytes Transcriptome profiling Amyotrophic lateral sclerosis Intron retention Motor neuron disease Neurodegeneration Reactive astrocytes Human induced pluripotent stem cell Rna sequencing 
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