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TranscriptomicsEyeless: Pitx3 mutant mouse line, Expression profiling of liver
A new mouse mutant arose spontaneously at the 5th inbred generation in a congenic C3H/He line. Since the mice suffered from anophthalmia or microphthalmia, we referred to this new mutant as eyeless (provisional gene symbol: eyl). The mutation follows an autosomal recessive pattern of inheritance and...
ORGANISM(S): Mus musculus 
2010-05-19 | E-GEOD-15336 | biostudies-arrayexpress
TranscriptomicsGenome-wide expression profiling analysis of a SMC6 mutant mouse model
The function of the SMC5-6 complex is less clear, but it has an important role in a variety of different DNA repair processes and in resolving recombination structures. Interestingly mutation at a highly conserved residue (Ser994) in the ATP hydrolysis motif in the SMC6 C-terminal domain, resulted i...
ORGANISM(S): Mus musculus 
2013-04-22 | E-GEOD-38737 | biostudies-arrayexpress
TranscriptomicsGenome-wide expression profiling analysis of a Hmgn1, 3 and 5 mutant mouse model
Members of the HMGN protein family bind to nucleosomes and affect chromatin structure and functions as transcription, replication and DNA repair as well as epigenetic modifications. Overexpression of Hmgn1 may be linked to the etiology of Down syndrome while underexpression may be linked to some leu...
ORGANISM(S): Mus musculus 
2013-07-03 | E-GEOD-39062 | biostudies-arrayexpress
TranscriptomicsRapamycin extends life span, but has limited effects on aging in mice
Rapamycin extends life span in mice, but it remains unclear if this compound also delays mammalian aging. Here, we present results from a comprehensive large-scale assessment of a wide rage of structural and functional aging phenotypes in mice. Rapamycin extended life span but showed few effects on ...
ORGANISM(S): Mus musculus 
2013-07-29 | E-GEOD-41018 | biostudies-arrayexpress
UnknownChanging Trends in Complications and Mortality Rates Among US Youth and Young Adults With HIV Infection in the Era of Combination Antiretroviral Therapy.
Not available
S-EPMC4657532 | biostudies-literature
UnknownEfficacy and Safety of NVX-CoV2373 in Adults in the United States and Mexico.
Not available
S-EPMC8693692 | biostudies-literature
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