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TranscriptomicsTranscriptional changes occurring in end-stage human SCA1 cerebellum.
RNA-Seq was performed in post-mortem SCA1 cerebellum at the end stage of the disease and an age/sex-matched control tissue from a healthy individual.
ORGANISM(S): Homo sapiens 
2020-02-18 | E-MTAB-7714 | biostudies-arrayexpress
TranscriptomicsRNA-seq of human mesenchymal stem cells inducibly overexpressing human ataxin-1(Q82)
A protein aggregation model of human ataxin-1(Q82) was generated in human mesenchymal cells using the Sleeping Beauty transposon system. These cells inducibly express the pathogenic protein that causes SCA1 disease. Here, we describe the transcriptional changes occurring in cells which contain diffe...
ORGANISM(S): Homo sapiens 
2020-02-18 | E-MTAB-7713 | biostudies-arrayexpress
ProteomicsEnabling phenotypic drug discovery for neurological mitochondrial DNA disorders with patient-derived neural progenitor cells
Mitochondrial DNA (mtDNA) mutations predominantly cause neurological diseases. Searching for therapeutic strategies is hindered by the absence of viable neural model systems due to the challenges of engineering mtDNA. We demonstrate that neural progenitor cells (NPCs), rapidly obtained from human in...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-31 | MSV000080849 | MassIVE
UnknownBlood culture practices and microbiological capacity for sepsis diagnostics in Europe (2021-2022): a cross-sectional analysis of the European Sepsis Care Survey.
Not available
S-EPMC12771334 | biostudies-literature
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