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TranscriptomicsTranscription profiling by array of human MCF-7 breast cancer cells
Estrogen-responsive genes were identified by transcript profiling of estrogen-treated MCF-7 breast cancer cells. The gene expression profile generated after estrogen treatment was compared with that following inducible expression of c-Myc or c-Zip (a deletion mutant of c-Myc that lacks the N-termina...
ORGANISM(S): Homo sapiens 
2008-10-25 | E-GEOD-11791 | biostudies-arrayexpress
UnknownEssential role for Gata2 in modulating lineage output from hematopoietic stem cells in zebrafish.
Not available
S-EPMC8288679 | biostudies-literature
GenomicsEvolutionary comparison of CTCF and YY1 binding in primate lymphoblastoid cell lines
We performed an evolutionary comparison of the binding of the TF CTCF in human, chimpanzee, gorilla, orang-utan, macaque, baboon and marmoset using lymphoblastoid cell lines (LCLs). We also probes YY1 binding in human, chimpanzee, orang-utan and baboon LCLs as well as human and mouse liver.
ORGANISM(S): Pan troglodytes 
2013-11-20 | E-MTAB-1511 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of yeast to investigate the involvement of Snf7 and Rim101 in regulation of TIR1 and anaerobically up-regulated genes
Despite the scientific and applied interest in anaerobic metabolism of Saccharomyces cerevisiae, not all genes whose transcription is up-regulated under anaerobic conditions have yet been linked to known transcription factors. Experiments with a reporter construct in which the promoter of the anaero...
ORGANISM(S): Saccharomyces cerevisiae 
2009-10-02 | E-GEOD-18128 | biostudies-arrayexpress
GenomicsDistinct factors control histone variant H3.3 localization at specific genomic regions
The incorporation of histone H3 variants has been implicated in the epigenetic memory of cellular state. Using genome editing with zinc finger nucleases to tag endogenous H3.3, we report genome-wide profiles of H3 variants in mammalian embryonic stem (ES) cells and neuronal precursor cells. Genome-w...
ORGANISM(S): Mus musculus 
2010-03-04 | E-GEOD-16893 | biostudies-arrayexpress
Transcriptomicsp21 as a transcriptional co-represor of S-phase and mitotic control genes-kp21
Our goal is to find new genes regulated by p21 in human primary cells . To get it we carried out a gene expression profiling in two different models, human myeloid leukemia K562 cells and human keratinocytes both of them with conditional expression of p21. In order to find genes regulated by p21 in...
ORGANISM(S): Homo sapiens 
2012-05-30 | E-MEXP-3431 | biostudies-arrayexpress
TranscriptomicsTime-course RNA-seq analysis in root and shoot tissues of zinc-deficient Triticum aestivum cv. Paragon (bread wheat)
The aim of this study was to investigate transcriptional changes underlying the zinc (Zn) deficiency response in root and shoot tissues of bread wheat. Triticum aestivum cv. Paragon seedlings were hydroponically grown and subjected to Zn starvation (0 μM ZnCl₂) starting at 14 days after germination....
ORGANISM(S): Triticum aestivum 
2026-08-24 | E-MTAB-15529 | biostudies-arrayexpress
GenomicsThe telomere-binding protein Tbf1 demarcates snoRNA gene promoters in Saccharomyces cerevisiae
The majority of Saccharomyces cerevisiae snoRNA promoters contain an aRCCCTaa sequence motif located at the upstream border of a TATA-containing nucleosome-free region. Genome-wide ChIP-seq analysis showed that these motifs are bound in vivo by Tbf1, a telomere-binding protein known to recognize mam...
ORGANISM(S): Saccharomyces cerevisiae 
2010-05-28 | E-GEOD-20870 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of S. cerervisiae chemostat growth samples reveals resistance to hop iso-I?-acids in yeast involves active export and vacuolar sequestration
The hop plant, Humulus lupulus L., contains an exceptionally high content of secondary metabolites, the hop iso-α-acids, which possess a range of beneficial properties including antiseptic action. Studies performed on the mode of action of hop iso-α-acids have hitherto been restricted to lactic ac...
ORGANISM(S): Saccharomyces cerevisiae 
2009-11-28 | E-GEOD-15094 | biostudies-arrayexpress
UnknownQuinolinic acid/tryptophan ratios predict neurological disease in SIV-infected macaques and remain elevated in the brain under cART.
Not available
S-EPMC4512924 | biostudies-literature
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