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TranscriptomicsMethyl-CpG-Binding Protein MBD2 plays a critical role in maintenance and spread of DNA methylation of CpG islands and shores in cancer (methylation)
Cancer is characterised by DNA hypermethylation and gene silencing of CpG island-associated promoters, including tumour suppressor genes The methyl-CpG-binding domain (MBD) family of proteins bind to methylated DNA and can aid in the meditation of gene silencing by interaction with histone deacetyla...
ORGANISM(S): Homo sapiens 
2016-08-24 | E-GEOD-77201 | biostudies-arrayexpress
TranscriptomicsMethyl-CpG-Binding Protein MBD2 plays a critical role in maintenance and spread of DNA methylation of CpG islands and shores in cancer
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Homo sapiens 
2016-08-24 | E-GEOD-77206 | biostudies-arrayexpress
TranscriptomicsDNA methylation of estrogen regulated enhancers defines endocrine sensitivity in breast cancer
Expression of estrogen receptor (ESR1) determines whether a breast cancer patient receives endocrine therapy as part of their adjuvant care, but does not guarantee patient response. However, the molecular factors that define endocrine response in ESR1-positive breast cancer patients remain poorly un...
ORGANISM(S): Homo sapiens 
2015-07-01 | E-GEOD-69118 | biostudies-arrayexpress
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