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GenomicsGenome-wide Analysis Reveals Conserved and Divergent Features of Notch1/RBPJ Binding in Human and Murine T Lymphoblastic Leukemia Cells
Notch1 regulates gene expression by associating with the DNA-binding factor RBPJ and is oncogenic in murine and human T cell progenitors. Using ChIP-Seq, we find that in human and murine T-LL genomes Notch1 binds preferentially to promoters, to RBPJ binding sites, and near imputed ZNF143, Ets and Ru...
ORGANISM(S): Mus musculus 
2011-07-06 | E-GEOD-29600 | biostudies-arrayexpress
ProteomicsDiscovery proteomics studies for the identification of a protein panel associated with the response to pemetrexed in platinum drug resistant cancer
Pemetrexed is a drug largely used in lung cancer, mesothelioma and proposed in some cases of ovarian cancers, a particularly severe cancer type. In this latest tumor type, therapy relies on debulking surgery and platinum-based chemotherapy. Despite the initial high response rates to platinum drugs, ...
ORGANISM(S): Homo sapiens (Human) 
2018-06-06 | PXD007056 | Pride
Platinum drug resistance Lc ms/ms Ovarian cancer Discovery proteomics 
GenomicsEpstein-Barr Virus Exploits Intrinsic B-Lymphocyte Transcription Programs to Achieve Immortal Cell Growth
Epstein-Barr Virus Nuclear Antigen 2 (EBNA2) gene regulation through the cell RBPJ transcription factor (TF) is essential for conversion of resting B-lymphocytes (RBLs) into Lymphoblastoid Cell Lines (LCLs). ChIP-seq investigation of EBNA2 and RBPJ sites in LCL DNA found EBNA2 at 5151 and RBPJ at 10...
ORGANISM(S): Homo sapiens 
2011-07-01 | E-GEOD-29498 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of Atlantic salmon cell line SHK-1 exposed to interferon type 1 and interferon gamma for 6 or 24 hours
We have stimulated an Atlantic salmon cell line, SHK-1, with both type I and type II recombinant salmonid IFNs and analysed the transcriptional response by microarray analysis. Cells were exposed to recombinant IFNs for 6 or 24 h or were left unexposed as controls. RNA was hybridised to a 17k feat...
ORGANISM(S): Salmo salar 
2007-10-08 | E-MEXP-1023 | biostudies-arrayexpress
UnknownMultimodal assessment of recovery from coma in a rat model of diffuse brainstem tegmentum injury.
Not available
S-EPMC6642798 | biostudies-literature
UnknownMicroRNA-125b protects against myocardial ischaemia/reperfusion injury via targeting p53-mediated apoptotic signalling and TRAF6.
Not available
S-EPMC4030511 | biostudies-literature
UnknownLineage-Specific Wnt Reporter Elucidates Mesenchymal Wnt Signaling during Bone Repair.
Not available
S-EPMC6180253 | biostudies-literature
UnknownIsolation and characterization of canine perivascular stem/stromal cells for bone tissue engineering.
Not available
S-EPMC5425216 | biostudies-literature
UnknownCultured Bacteria Provide Insight into the Functional Potential of the Coral-Associated Microbiome.
Not available
S-EPMC9426491 | biostudies-literature
UnknownA coral-associated actinobacterium mitigates coral bleaching under heat stress.
Not available
S-EPMC10668361 | biostudies-literature
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