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TranscriptomicsHigh-throughput ectopic expression screen for tamoxifen resistance
Resistance to tamoxifen in breast cancer patients is a serious therapeutic problem and major efforts are underway to understand underlying mechanisms. Resistance can be either intrinsic or acquired. We derived a series of subcloned MCF7 cell lines that were either highly sensitive or naturally resis...
ORGANISM(S): Homo sapiens 
2011-01-06 | E-GEOD-26459 | biostudies-arrayexpress
GenomicsJmjd3-mediated H3K27me3 dynamics orchestrate brown fat cell fate transition and regulate white fat plasticity
We performed ChIP-seq to chart genome-wide maps of H3K27me3 in brown preadipocytes and mature brown adipocytes. We observed a subset of brown fat-specific genes, but not common fat genes or white fat-specific genes, possess the H3K27me3 mark in preadipocytes, and this mark is erased in mature adipoc...
ORGANISM(S): Mus musculus 
2015-12-31 | E-GEOD-55469 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human MCF7/BUS cell culture exposed to xenoestrogens
MCF7 cells were exposed to xenoestrogens (vehicle = 0.1% ethanol, 30 pM 17beta-estradiol, 3 micromolar genistein, 10 micromolar genistein, 1 micomolar daidzein, 10 nM bisphenol A, 10 nM para-nonylphenol, 3 nM PPT) for 48 hours. Experiment Overall Design: MCF7/BUS cells were exposed to xenoestrogens ...
ORGANISM(S): Homo sapiens 
2008-06-13 | E-GEOD-5200 | biostudies-arrayexpress
TranscriptomicsJmjd3-mediated H3K27me3 dynamics orchestrate brown fat cell fate transition and regulate white fat plasticity (RNA-Seq)
We performed RNA-Seq for brwon fat, epididymal white fat and soleus muscle of mice to identify brown fat-selective, white fat-selective and common fat genes. RNA-Seq for brown fat, white fat and soleus muscle of wild type C56BL6 mice.
ORGANISM(S): Mus musculus 
2015-12-31 | E-GEOD-56367 | biostudies-arrayexpress
MetabolomicsGut Microbiota Regulates Serum Metabolites in Mice with Nonalcoholic Fatty Liver Disease via Gut Metabolites: Mechanisms Involving Branched-Chain Amino Acids and Unsaturated Fatty Acids

In recent years, nonalcoholic fatty liver disease (NAFLD) has become the most common chronic liver disease globally. Studies indicate that the gut-liver axis plays an important role in the occurrence and development of this disease. Our previous studies showed that the gut microbiota and gut meta...

2025-07-02 | MTBLS12668 | MetaboLights
ProteomicsGlycopeptidomics Analysis of a Cell Line Model Revealing Pathogenesis and Potential Marker Molecules for the Early Diagnosis of Gastric MALT Lymphoma
The relationship between the predominant glycoforms of host cells and the development of host disease was determined
ORGANISM(S): Homo Sapiens X Mus Musculus Hybrid Cell Line 
2021-06-25 | PXD026920 |
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