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TranscriptomicsTranscription profiling of Plasmodium falciparum synchronized blood stages exposed to lethal doses of artesunate
Each experiment consisted in an artesunate-free culture (control) and an artesunate treated culture. For each time point explored, cDNA from parasites with and without the drug were labeled with different cyanines, mixed and hybridized. To analyse dynamic transcriptome alterations, two pilot experim...
ORGANISM(S): Plasmodium falciparum 
2008-06-01 | E-MEXP-1435 | biostudies-arrayexpress
GenomicsArtesunate Protects against Sepsis-induced Cardiomyopathy
Artesunate Protects against Sepsis-induced Cardiomyopathy
PRJNA1406122 | ENA
GenomicsDifferential Gene expression anslysis between artesunate sensitive and resistat Leishmania donovani
Differential Gene expression anslysis between artesunate sensitive and resistat Leishmania donovani
PRJNA485727 | ENA
ClinicalPhase I study of oral artesunate in colorectal cancer
Study hypothesis: The primary objective of the study is to determine the anti-cancer effect of oral artesunate in colorectal adenocarcinoma defined as the proportion of malignant cells undergoing apoptosis. Secondary outcome measures are to establish the tolerability of oral artesunate in colorectal...
2407459 | ecrin-mdr-crc
TranscriptomicsDifferential Gene expression anslysis between artesunate sensitive and resistat Leishmania donovani
Gene expression analysis was carried out between experimental artesunate resistant Leishmania donovani (adapted to 50 µM artesunate drug pressure) and it's corresponding wild type artesunate sensitive parasite.
ORGANISM(S): Leishmania donovani 
2019-08-30 | GSE118460 | GEO
Methylation profilingExploring the molecular mechanism of artesunate intervening in glioma based on DNA methylation sequencing technology
Whole gene methylation profiles of U87 and U251 glioma cells before and after artesunate treatment, Infinium MethylationEPIC BeadChip, samples including 3 U87 cell normal group, 3 U251 cell normal group, 3 artesunate treated U87 cell group,  U251 cell group was treated with 3 artesunate.
ORGANISM(S): Homo sapiens 
2022-10-18 | GSE215784 | GEO
GenomicsExploring the molecular mechanism of artesunate intervening in glioma based on DNA methylation sequencing technology
Exploring the molecular mechanism of artesunate intervening in glioma based on DNA methylation sequencing technology
PRJNA890608 | ENA
ClinicalA Safety and Effectiveness Study of Pre-operative Artesunate in Stage II/III Colorectal Cancer
This study evaluates the safety and effectiveness of pre-operative artesunate given orally once a day for 14 days prior to surgery in patients with Stage II/III colorectal cancer. Artesunate is an established antimalarial drug with an excellent safety profile, is well tolerated and affordable. A num...
2204487 | ecrin-mdr-crc
TranscriptomicsArtesunate inhibits the cell viability of diffuse large B cell lymphoma cells by increasing the susceptibility to ferroptosis (RNA-seq).
Comparing the effects of artesunate versus DMSO in three DLBCL cell lines, we found a decrease in cell viability to 80%-60%. Over increasing artesunate dosage,we found increasing ROS generation and lipid peroxidation. In combination with the Ferrostatin-1 rescue experiment, we conclude that cell dea...
ORGANISM(S): Homo sapiens 
2024-03-06 | GSE260741 | GEO
UnknownDelayed-onset hemolytic anemia in patients with travel-associated severe malaria treated with artesunate, France, 2011-2013.
Not available
S-EPMC4412216 | biostudies-literature
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