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TranscriptomicsThe role of the Ras- and cAMP-signaling pathways in stress response and sterol biosynthesis in Cryptococcus neoformans
The cAMP-pathway plays a central role in regulation of growth, differentiation, and virulence of human pathogenic fungi, including Cryptococcus neoformans. Three major upstream signaling regulators of the adenylyl cyclase (Cac1), Ras, Aca1 (Adenylyl cyclase-associated protein 1) and G-alpha subunit ...
ORGANISM(S): Cryptococcus neoformans var. grubii H99 
2010-05-22 | E-GEOD-17338 | biostudies-arrayexpress
TranscriptomicsRemodeling of global transcription patterns of C. neoformans genes mediated by stress-activated HOG signaling pathways
The ability to sense and adapt to a hostile host environment is a crucial element for virulence of pathogenic fungi, including Cryptococcus neoformans. These cellular responses are evoked by diverse signaling cascades, including the stress-activated HOG pathway. Despite previous analysis of centra...
ORGANISM(S): Cryptococcus neoformans var. grubii 
2010-05-17 | E-GEOD-16692 | biostudies-arrayexpress
TranscriptomicsComparative transcriptome analysis of the CO2 sensing pathway via differential expressions of carbonic anhydrase in Cryptococcus neoformans
Carbon dioxide (CO2) sensing, transport, and metabolism play a pivotal role in survival and proliferation of pathogenic microbes infecting human host from natural environments due to the drastic difference of CO2 levels. Carbonic anhydrases (CAs) are not only key CO2-metabolic enzymes catalyzing rev...
ORGANISM(S): Cryptococcus neoformans var. grubii H99 
2010-05-31 | E-GEOD-21192 | biostudies-arrayexpress
TranscriptomicsCoCl2 Response in Cryptococcus neoformans
We investigated the effects of the hypoxia-mimetic CoCl2 on the gene expression of pathogenic fungus Cryptococcus neoformans. Keywords: compound treatment design Three biological repeats were performed using three independent RNA sets isolated from cells cultured on different days and the dye-revers...
ORGANISM(S): Filobasidiella neoformans 
2010-05-19 | E-GEOD-11390 | biostudies-arrayexpress
TranscriptomicsOverexpression of the transcription factor GAT201 in Cryptococcus neoformans var. grubii (serotype A, H99)
Comparison of transcriptional profiles of WT Cryptococcus neoformans (H99) and strain CM126 (pRPL2b-GAT201) which overexpresses the transcription factor GAT201 using a ribosomal protein promoter Keywords: Genetic modification WT vs. CM126 competitive hybridization. 4 biological replicates including...
ORGANISM(S): Filobasidiella neoformans 
2010-05-26 | E-GEOD-10750 | biostudies-arrayexpress
TranscriptomicsHapX positively and negatively regulates the transcriptional response to iron deprivation in Cryptococcus neoformans
Analysis of the transcriptional response of C. neoformans WT, cir1 mutant, hap3 mutant and hapX mutant to different iron sources. The following experimental design was adopted for the study. Within each strain, each treatment pair (low-iron, +FeCl3, +Transferrin and +Hemin; 6 pairs) were hybridized ...
ORGANISM(S): Cryptococcus neoformans 
2011-04-13 | E-GEOD-22988 | biostudies-arrayexpress
TranscriptomicsLight-regulated genes in Cryptococcus neoformans
Light is a universal environmental signal perceived by many organisms, including the fungi in which light regulates both common and unique biological processes depending on the species. We conducted a whole-genome microarray analysis on the basidiomycete fungus Cryptococcus neoformans to identify li...
ORGANISM(S): Cryptococcus neoformans var. neoformans 
2010-04-23 | E-GEOD-21484 | biostudies-arrayexpress
TranscriptomicsChromosome copy number variation in Cryptococcus neoformans influences virulence and occurs in isolates from AIDS patients
Influence of copy number changes at several chromosomes to melanin production and virulence of Cryptococcus neoformans Black(B4) and white(W2) strains were compared to each other. Black variant from white strain (W2BA1) is also compared to the black strain(B4).
ORGANISM(S): Cryptococcus neoformans 
2011-04-19 | E-GEOD-28673 | biostudies-arrayexpress
TranscriptomicsRole of Cryptococcus neoformans Sre1-pathway in low oxygen gene expression
Comparison of wild-type serotype A C. neoformans cells grown at 21% and 3% oxygen for 2 hours in rich medium. Also comparison of wild-type and Sre1-pathway mutant strains grown at 3 % oxygen for 2 hours in rich medium. Two-condition experiment. Each comparison was performed in two biological replic...
ORGANISM(S): Filobasidiella neoformans 
2010-05-22 | E-GEOD-18282 | biostudies-arrayexpress
TranscriptomicsA defect in iron uptake enhances the susceptibility of Cryptococcus neoformans to azole antifungal drugs.
Transcriptome profiling of wild type and cfo1 mutant with fluconazole treatment in Cryptococcus neoformans var. grubii H99 Purpose: The goals of this study are to compare cfo1 mutant transcriptome profiling (RNA-seq) to wild-type with or without fluconazole treatment in Cryptococcus neoformans var. ...
ORGANISM(S): Cryptococcus neoformans var. grubii H99 
2013-05-31 | E-GEOD-37875 | biostudies-arrayexpress
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