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MetabolomicsEvaluation of significant features discovered from different data acquisition modes in mass spectrometry-based untargeted metabolomics

Despite the growing popularity of liquid chromatography-mass spectrometry (LC-MS)-based metabolomics, no study has yet to systematically compare the performance of different data acquisition modes in the discovery of significantly altered metabolic features, which is an important task of untarget...

2020-10-02 | MTBLS1842 | MetaboLights
TranscriptomicsaCGH study of iPS cells from two normal subjects and two Parkinson's disease patients with parkin mutations
Parkinson's disease (PD) is defined by the degeneration of nigral dopaminergic (DA) neurons and can be caused by monogenic mutations of genes such as parkin. The lack of phenotype in parkin knockout mice suggests that human nigral DA neurons have unique vulnerabilities. Here we generate induced plur...
ORGANISM(S): Homo sapiens 
2012-01-21 | E-GEOD-35190 | biostudies-arrayexpress
MetabolomicsHuman umbilical cord-derived mesenchymal stem cells ameliorate perioperative neurocognitive disorder by inhibiting inflammatory responses and activating BDNF/TrkB/CREB signaling pathway in aged mice

BACKGROUND: Perioperative neurocognitive disorder (PND) is a key complication affecting older individuals after anesthesia and surgery. Failure to translate multiple pharmacological therapies for PND from preclinical studies to clinical settings has necessitated the exploration o...

2023-07-25 | MTBLS7759 | MetaboLights
ProteomicsMass spec analysis of the sequences of proteins snFPITE-n1 and snFPITE-n2 from Sipunculus nudus
In this project, we purified proteins snFPITE-n1 and snFPITE-n2 from Sipunculus nudus, digested the proteins and determined the sequences of the proteins by Mass spec analysis. We have a database of the sequences of snFPITE proteins from Sipunculus nudus and we used the Mass spec results to search f...
ORGANISM(S): Sipunculus nudus 
2025-04-03 | PXD043675 | Pride
Sipunculus nudus Mass spec 
UnknownHuman whole-exome genotype data for Alzheimer's disease.
Not available
S-EPMC10805795 | biostudies-literature
UnknownA rare missense variant of CASP7 is associated with familial late-onset Alzheimer's disease.
Not available
S-EPMC6408965 | biostudies-literature
UnknownGenetic architecture of subcortical brain structures in 38,851 individuals.
Not available
S-EPMC7055269 | biostudies-literature
UnknownThe functional spectrum of low-frequency coding variation.
Not available
S-EPMC3308047 | biostudies-literature
UnknownDiversity of human copy number variation and multicopy genes.
Not available
S-EPMC3020103 | biostudies-literature
UnknownA map of human genome variation from population-scale sequencing.
Not available
S-EPMC3042601 | biostudies-literature
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