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UnknownCirculating lymphocytes and monocytes transcriptomic analysis of patients with type 2 diabetes mellitus, dyslipidemia and periodontitis.
Type 2 diabetes mellitus (T2DM), dyslipidemia and periodontitis are frequently associated pathologies; however, there are no studies showing the peripheral blood transcript profile of these combined diseases. Here we identified the differentially expressed genes (DEGs) of circulating lymphocytes and...
S-EPMC7235087 | biostudies-literature
UnknownEffect of Lung Recruitment and Titrated Positive End-Expiratory Pressure (PEEP) vs Low PEEP on Mortality in Patients With Acute Respiratory Distress Syndrome: A Randomized Clinical Trial.

Importance

The effects of recruitment maneuvers and positive end-expiratory pressure (PEEP) titration on clinical outcomes in patients with acute respiratory distress syndrome (ARDS) remain uncertain.

Objective

To determine if lung recruitment associated with PEEP titration according ...
S-EPMC5710484 | biostudies-literature
MetabolomicsGeographic variation of mutagenic exposures in kidney cancer genomes

International differences in the incidence of many cancer types indicate the existence of carcinogen exposures that have not been identified by conventional epidemiology yet potentially make a substantial contribution to cancer burden1. This pertains to clear cell renal cell carcinoma (ccRCC), fo...

2024-03-26 | MTBLS9394 | MetaboLights
UnknownApplications of Non-invasive Neuromodulation for the Management of Disorders Related to COVID-19.
Background: Novel coronavirus disease (COVID-19) morbidity is not restricted to the respiratory system, but also affects the nervous system. Non-invasive neuromodulation may be useful in the treatment of the disorders associated with COVID-19. Objective: To describe the rationale and e...
S-EPMC7724108 | biostudies-literature
UnknownZika Virus Surveillance at the Human-Animal Interface in West-Central Brazil, 2017-2018.
Zika virus (ZIKV) was first discovered in 1947 in Uganda but was not considered a public health threat until 2007 when it found to be the source of epidemic activity in Asia. Epidemic activity spread to Brazil in 2014 and continued to spread throughout the tropical and subtropical regions of the Ame...
S-EPMC6950091 | biostudies-literature
UnknownInternational Consensus for the Dosing of Corticosteroids in Childhood-Onset Systemic Lupus Erythematosus With Proliferative Lupus Nephritis.

Objective

To develop a standardized steroid dosing regimen (SSR) for physicians treating childhood-onset systemic lupus erythematosus (SLE) complicated by lupus nephritis (LN), using consensus formation methodology.

Methods

Parameters influencing corticosteroid (CS) dosing were identi...
S-EPMC8766607 | biostudies-literature
UnknownThe first Miocene fossils from coastal woodlands in the southern East African Rift.
The Miocene was a key time in the evolution of African ecosystems witnessing the origin of the African apes and the isolation of eastern coastal forests through an expanding arid corridor. Until recently, however, Miocene sites from the southeastern regions of the continent were unknown. Here, we re...
S-EPMC10494320 | biostudies-literature
UnknownOne Month of Rifapentine plus Isoniazid to Prevent HIV-Related Tuberculosis.

Background

Tuberculosis is the leading killer of patients with human immunodeficiency virus (HIV) infection. Preventive therapy is effective, but current regimens are limited by poor implementation and low completion rates.

Methods

We conducted a randomized, open-label, phase 3 noninf...
S-EPMC6563914 | biostudies-literature
UnknownDigitalized transcranial electrical stimulation: A consensus statement.

Objective

Although relatively costly and non-scalable, non-invasive neuromodulation interventions are treatment alternatives for neuropsychiatric disorders. The recent developments of highly-deployable transcranial electric stimulation (tES) systems, combined with mobile-Health technologies,...
S-EPMC10031774 | biostudies-literature
UnknownEarly Treatment with Pegylated Interferon Lambda for Covid-19.

Background

The efficacy of a single dose of pegylated interferon lambda in preventing clinical events among outpatients with acute symptomatic coronavirus disease 2019 (Covid-19) is unclear.

Methods

We conducted a randomized, controlled, adaptive platform trial involving predominantly...
S-EPMC9933926 | biostudies-literature
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