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TranscriptomicsDifferentiation and specification of resident tissue macrophages [MARS-seq]
Tissue resident macrophages are functionally diverse cells that share an embryonic mesodermal origin. However, the mechanism(s) that control their specification remain unclear. We performed transcriptional, molecular and in situ spatio-temporal analyses of macrophage development in mice. We report t...
ORGANISM(S): Mus musculus 
2016-08-08 | E-GEOD-81760 | biostudies-arrayexpress
TranscriptomicsDifferentiation and specification of resident tissue macrophages [SMART-Seq2]
Tissue resident macrophages are functionally diverse cells that share an embryonic mesodermal origin. However, the mechanism(s) that control their specification remain unclear. We performed transcriptional, molecular and in situ spatio-temporal analyses of macrophage development in mice. We report t...
ORGANISM(S): Mus musculus 
2016-08-08 | E-GEOD-81686 | biostudies-arrayexpress
UnknownDevelopment of siRNA-Loaded Lipid Nanoparticles Targeting Long Non-Coding RNA LINC01257 as a Novel and Safe Therapeutic Approach for t(8;21) Pediatric Acute Myeloid Leukemia.
Not available
S-EPMC8539450 | biostudies-literature
GenomicsChromatin accessibility maps of chronic lymphocytic leukemia identify subtype-specific epigenome signatures and transcription regulatory networks
Chronic lymphocytic leukemia (CLL) is characterized by substantial clinical heterogeneity, despite relatively few genetic alterations. To provide a basis for studying epigenome deregulation in CLL, we established genome-wide chromatin accessibility maps for 88 CLL samples from 55 patients using the ...
ORGANISM(S): Homo sapiens 
2016-06-26 | E-GEOD-81274 | biostudies-arrayexpress
UnknownSuz12 inactivation cooperates with JAK3 mutant signaling in the development of T-cell acute lymphoblastic leukemia.
Not available
S-EPMC6888143 | biostudies-literature
TranscriptomicsPaternally-induced transgenerational environmental reprogramming of metabolic gene expression in mammals
This SuperSeries is composed of the following subset Series: GSE25895: Paternally-induced transgenerational environmental reprogramming of metabolic gene expression in mammals (dye swap) GSE25896: Paternally-induced transgenerational environmental reprogramming of metabolic gene expression in mammal...
ORGANISM(S): Mus musculus 
2011-01-14 | E-GEOD-25899 | biostudies-arrayexpress
UnknownDefining the molecular basis of oncogenic cooperation between TAL1 expression and Pten deletion in T-ALL using a novel pro-T-cell model system.
Not available
S-EPMC5886055 | biostudies-literature
TranscriptomicsDevelopment of gene expression signatures for GSI treatment of the ALL-SIL cell line.
The T-cell leukemia homeobox 1 (TLX1, HOX11) transcription factor is critically involved in the multistep pathogenesis of T-cell acute lymphoblastic leukemia (T-ALL) and often cooperates with NOTCH1 activation during malignant T-cell transformation. However, the exact molecular mechanisms by which t...
ORGANISM(S): Homo sapiens 
2015-08-05 | E-GEOD-70629 | biostudies-arrayexpress
TranscriptomicsPaternally-induced transgenerational environmental reprogramming of metabolic gene expression in mammals (small RNA)
Characterized the small (19-35 bp) RNA population from control and low protein offspring livers by high throughput sequencing. Eight sequencing lanes, one for each animal, with an average of 3.7 million mappable reads per lane. A number of miRNAs changed expression in the offspring from low protein ...
ORGANISM(S): Mus musculus 
2011-01-14 | E-GEOD-25897 | biostudies-arrayexpress
UnknownVersailles Project on Advanced Materials and Standards Interlaboratory Study on Measuring the Thickness and Chemistry of Nanoparticle Coatings Using XPS and LEIS.
Not available
S-EPMC5093768 | biostudies-literature
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