Sort   by:  
 Page size 
TranscriptomicsscRNA-seq of E9.5 para-aortic splanchnopleura from NCX1-null embryos and wild type controls
In order to study the effect of Ncx1 deletion on the HSC-supportive microenviromrent in the AGM niche, caudal parts from E9.5 (20-23 sp) Ncx1-/- and Ncx1+/+ littermate controls (4 embryos/group) were dissected and processed into single cell suspensions and dead/damaged cells were removed by magnetic...
ORGANISM(S): Mus musculus 
2021-12-14 | E-MTAB-10945 | biostudies-arrayexpress
TranscriptomicsSingle-nuclei Multiome (RNA+ATAC) analysis of embryonic AGM+VU from Runx1 +23 enhancer-reporter transgenic mouse
During embryonic development, haematopoietic stem and progenitor cells originate from haemogenic endothelium (HE) via an endothelial-to-haematopoietic transition (EHT), which is dependent on the transcription factor Runx1. Here, we measure gene expression and DNA accessibility in single nuclei isola...
ORGANISM(S): Mus musculus 
2026-07-31 | E-MTAB-15412 | biostudies-arrayexpress
GenomicsCombinatorial Transcriptional Control in Blood Stem/Progenitor Cells: Genome-wide Analysis of 10 major Transcriptional Regulators
Combinatorial transcription factor (TF) interactions control cellular phenotypes and therefore underpin stem cell formation, maintenance and differentiation. Here we report the genome-wide binding patterns and combinatorial interactions for 10 key regulators of blood stem/progenitor cells (Scl/Tal1,...
ORGANISM(S): Mus musculus 
2010-10-07 | E-GEOD-22178 | biostudies-arrayexpress
GenomicsA fully validated blood stem/progenitor cell regulatory network reveals mechanisms of cell state stabilisation
The aim of this study was to determine the genomic binding sites of important haematopoietic transcription factors in haematopoietic cell lines. 416Bs cells were fixed with either 1 or 0.4 % formaldehyde for 10 mins. Chromatin was isolated, sonicated for 7 mins (30 sec on, 30 sec off), and specific ...
ORGANISM(S): Mus musculus 
2016-03-17 | E-GEOD-69776 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse Scl -/- yolk sac cell line after reintroduction of Scl by protein transduction
Expression profile of Scl -/- yolk sac cell line after reintroduction of Scl
ORGANISM(S): Mus musculus 
2008-01-09 | E-TABM-397 | biostudies-arrayexpress
Sort   by:  
 Page size