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TranscriptomicsInterstrain differences in the severity of liver injury induced by a choline- and folate-deficient diet in mice are associated with dysregulation of genes involved in lipid metabolism.
Nonalcoholic fatty liver disease (NAFLD) is a major health problem and a leading cause of chronic liver disease in the United States and developed countries. In humans, genetic factors greatly influence individual susceptibility to NAFLD. The goals of this study were to compare the magnitude of inte...
ORGANISM(S): Mus musculus 
2014-10-16 | E-GEOD-62362 | biostudies-arrayexpress
TranscriptomicsGenotoxic, epigenetic, and transcriptomic effects of tamoxifen in mouse liver
Tamoxifen is a non-steroidal anti-estrogenic drug widely used for the treatment and prevention of breast cancer in women; however, there is evidence that tamoxifen is hepatocarcinogenic in rats, but not in mice. Additionally, it has been reported that tamoxifen may cause non-alcoholic fatty liver di...
ORGANISM(S): Mus musculus 
2014-10-11 | E-GEOD-62267 | biostudies-arrayexpress
TranscriptomicsCerebellar oxidative DNA damage and altered DNA methylation in the BTBR T+tf/J mouse model of autism and similarities with human post mortem cerebellum.
The molecular pathogenesis of autism is complex and involves numerous genomic, epigenomic, proteomic, metabolic, and physiological alterations. Elucidating and understanding the molecular processes underlying the pathogenesis of autism is critical for effective clinical management and prevention of...
ORGANISM(S): Mus musculus 
2014-10-23 | E-GEOD-62594 | biostudies-arrayexpress
TranscriptomicsHepatic transcriptomic changes during non-alcoholic steatohepatitis (NASH)-associated liver carcinogenesis in mice
Hepatocellular carcinoma (HCC), which accounts for 90% of all primary livers tumors, is the fourth most common cancer in the world. The development of HCC is a long-term and complex process, and uncovering the molecular mechanisms associated with HCC development is critical for the disease diagnosi...
ORGANISM(S): Mus musculus 
2016-06-22 | E-GEOD-83596 | biostudies-arrayexpress
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