de Koning Harry H

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(5Z,7E,22E,24E,26E)-(1S,3R)-26a,26b-dihomo-27-nor-9,10-seco-5,7,10(19),22,24,26(26a)-cholestahexaene-1,3,26b-triol (1)
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2017 (1)

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Novel Minor Groove Binders cure animal African trypanosomiasis in an in vivo mouse model

Animal African trypanosomiasis (AAT) is a significant socioeconomic burden for sub-Saharan Africa because of its huge impact on livestock health. Existing therapies including those based on minor groove binders (MGBs), such as the diamidines, which have been used for decades, have now lost efficacy ...

2022-01-18 | MTBLS882 | MetaboLights

Divergent metabolism between Trypanosoma congolense and Trypanosoma brucei results in differential sensitivity to metabolic inhibition

Animal African Trypanosomiasis (AAT) is a debilitating livestock disease prevalent across sub-Saharan Africa, a main cause of which is the protozoan parasite Trypanosoma congolense. In comparison to the well-studied T. brucei, there is a major paucity of knowledge regarding the biology of T. congole...

2021-07-20 | MTBLS2372 | MetaboLights

Islet cells share promoter hypomethylation independently of expression, but exhibit cell-type-specific methylation in enhancers.

Not available

S-EPMC5754795 | biostudies-literature

WEHI991 drug target identification by DIA Solvent PISA

Here we demonstrate PfSTART1 engagement by WEHI991 in the P. falciparum proteome using organic solvent-based Proteome Integral Solubility Alteration (Solvent PISA) assay coupled with Data Independent Acquisition Mass Spectrometry (DIA-MS).

ORGANISM(S): Plasmodium (plasmodium)

2024-05-01 | PXD048262 | JPOST Repository

Mapping the human genetic architecture of COVID-19.