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UnknownRandomized Phase Ib/II Study of Gemcitabine Plus Placebo or Vismodegib, a Hedgehog Pathway Inhibitor, in Patients With Metastatic Pancreatic Cancer.
Not available
S-EPMC4678179 | biostudies-literature
GenomicsGenentech Data Access Committee
Data Access Committee EGAC00001000055
EGAC00001000055 | EGA
ProteomicsRepurposing E3 ubiquitin ligases as cell surface protein degraders using Proteolysis Targeting Antibodies
The majority of current therapeutics targeting plasma membrane receptors function by antagonizing ligand binding or enzymatic activities. Typical mammalian proteins, however, consist of multiple domains executing discrete but coordinated activities, and saturating inhibition of one functional domain...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2022-05-25 | MSV000089542 | MassIVE
GenomicsGenentech whole genome and transcriptome sequencing of four hepatocellular carcinoma patients

Hepatitis B virus (HBV) infection is a major risk factor for hepatocellular carcinoma (HCC). In this study we sequenced the whole genome (~80X) and transcriptome of tumor and non-tumor samples from four HCC patients and identified over two hundred HBV integration sites. We found significant clona...

phs000384.v1.p1 | EGA
GenomicsColon_Illumina_2.5M_Controls - samples
Colon matched tumour samples
EGAD00010000274 | EGA
GenomicsColon_Illumina_2.5M_Cases - samples
Colon tumour samples
EGAD00010000272 | EGA
Genomicsena-DATASET-Genentech-10-08-2012-19:54:35:559-18 - samples
Exome capture sequencing of colon tumor/normal pairs
EGAD00001000216 | EGA
Genomicsena-DATASET-Genentech-10-08-2012-19:45:02:785-17 - samples
RNA sequencing of colon tumor/normal sample pairs
EGAD00001000215 | EGA
Genomicsena-DATASET-Genentech-10-08-2012-19:36:55:498-15 - samples
Whole genome sequencing of colon samples
EGAD00001000214 | EGA
GenomicsGenentech Colon Cancer Screen
Identifying and understanding changes in cancer genomes is essential for the development of targeted therapeutics. Here we analyse systematically more than 70 pairs of primary human colon tumours by applying next-generation sequencing to characterize their exomes, transcriptomes and copy-number alte...
EGAS00001000288 | EGA
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