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UnknownValproic acid as adjuvant treatment for convulsive status epilepticus: a randomised clinical trial.

Background

Generalised convulsive status epilepticus (GCSE) is a medical emergency. Guidelines recommend a stepwise strategy of benzodiazepines followed by a second-line anti-seizure medicine (ASM). However, GCSE is uncontrolled in 20-40% patients and is associated with protracted hospitalis...
S-EPMC9830759 | biostudies-literature
UnknownBack-to-back comparison of penKID with NephroCheck® to predict acute kidney injury at admission in intensive care unit: a brief report.
Not available
S-EPMC5789637 | biostudies-literature
UnknownDeterminants of long-term outcome in ICU survivors: results from the FROG-ICU study.

Background

Intensive care unit (ICU) survivors have reduced long-term survival compared to the general population. Identifying parameters at ICU discharge that are associated with poor long-term outcomes may prove useful in targeting an at-risk population. The main objective of the study was...
S-EPMC5774139 | biostudies-literature
UnknownOutcomes of patients admitted to intensive care units for acute manifestation of small-vessel vasculitis: a multicenter, retrospective study.

Background

The outcomes of patients admitted to the intensive care unit (ICU) for acute manifestation of small-vessel vasculitis are poorly reported. The aim of the present study was to determine the mortality rate and prognostic factors of patients admitted to the ICU for acute small-vessel...
S-EPMC4729170 | biostudies-literature
UnknownImpact of Prone Position in COVID-19 Patients on Extracorporeal Membrane Oxygenation.

Objectives

Prone positioning and venovenous extracorporeal membrane oxygenation (ECMO) are both useful interventions in acute respiratory distress syndrome (ARDS). Combining the two therapies is feasible and safe, but the effectiveness is not known. Our objective was to evaluate the potentia...
S-EPMC9749944 | biostudies-literature
UnknownEfficacy and safety of baricitinib in hospitalized adults with severe or critical COVID-19 (Bari-SolidAct): a randomised, double-blind, placebo-controlled phase 3 trial.

Background

Baricitinib has shown efficacy in hospitalized patients with COVID-19, but no placebo-controlled trials have focused specifically on severe/critical COVID, including vaccinated participants.

Methods

Bari-SolidAct is a phase-3, multicentre, randomised, double-blind, placebo-...
S-EPMC9830601 | biostudies-literature
UnknownA novel urinary biomarker predicts 1-year mortality after discharge from intensive care.
RATIONALE:The urinary proteome reflects molecular drivers of disease. OBJECTIVES:To construct a urinary proteomic biomarker predicting 1-year post-ICU mortality. METHODS:In 1243 patients, the urinary proteome was measured on ICU admission, using capillary electrophoresis coupled with mass spectromet...
S-EPMC6953276 | biostudies-literature
UnknownTreatments for intracranial hypertension in acute brain-injured patients: grading, timing, and association with outcome. Data from the SYNAPSE-ICU study.

Purpose

Uncertainties remain about the safety and efficacy of therapies for managing intracranial hypertension in acute brain injured (ABI) patients. This study aims to describe the therapeutical approaches used in ABI, with/without intracranial pressure (ICP) monitoring, among different pat...
S-EPMC9852114 | biostudies-literature
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