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TranscriptomicsTranscription profiling of wild type, p53 Ser389 phosphorylation site point mutant and p53 knock-out mouse embryonic fibroblasts after exposure to UV radiation for different lengths of time
Comparison of responses of mouse wild-type, p53 Ser389 phosphorylation site point mutant and full knock-out mutant MEF cells to UV-C-radiation in time
ORGANISM(S): Mus musculus 
2008-06-01 | E-MEXP-1397 | biostudies-arrayexpress
TranscriptomicsUV-C dose and time range finding study on Mouse Embryonic Fibroblasts (MEFs)
In molecular biology, the design of mechanistic experiments has to be optimized by considering statistical and biological principles. In contrast to statistical principles, biological principles of experimental design are not universally formulated. In an attempt to pinpoint generally acceptable rul...
ORGANISM(S): Mus musculus 
2014-09-01 | E-GEOD-50930 | biostudies-arrayexpress
TranscriptomicsUV-B dose and time range finding study on mouse biopsy skin samples
In molecular biology, the design of mechanistic experiments has to be optimized by considering statistical and biological principles. In contrast to statistical principles, biological principles of experimental design are not universally formulated. In an attempt to pinpoint generally acceptable rul...
ORGANISM(S): Mus musculus 
2014-09-01 | E-GEOD-51348 | biostudies-arrayexpress
TranscriptomicsEffect of multiple longitudinal biopsy sampling in individual mice
Small scale study to asses the effects of taking multiple skinbiopts from individual mice in time. Results showed no influence on expression levels in time from older samplings on newer samplings. skin biopts from 4 individual mice in taken at 6 points in time
ORGANISM(S): Mus musculus 
2014-09-01 | E-GEOD-51347 | biostudies-arrayexpress
TranscriptomicsConfounding factors in the analysis of the transcriptome response to UV exposure in skin of wild-type and human p53-variant mice
An in-vivo experiment with UV-B exposure of the skin of nude, male mice, with and without human-derived p53 variants in their genome to investigate the cellular responses upon UV-induced DNA damage. Essentially, 4 replicate mice were used for each level of UV-exposure. For each mouse a biopsy of the...
ORGANISM(S): Mus musculus 
2016-03-01 | E-GEOD-63044 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of lung tissue from transcription-coupled repair-deficient (Csb-/-) and wild type mice in response to ozone
We investigated whether transcription-coupled repair deficient mice (Cockayne syndrome B knockout mice (Csb-/-)), known to be sensitive to oxidative stressors, have a different response to ozone than its repair-proficient control, Csb heterozygote (Csb+/-) mice.
ORGANISM(S): Mus musculus 
2006-11-13 | E-TABM-137 | biostudies-arrayexpress
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