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TranscriptomicsTranscription profiling of liver from Csbm/m/Xpa-/- knockout mice to investigate the effect of nucleotide excision repair pathway inactivation
Cockayne syndrome (CS) is a photosensitive, DNA repair disorder associated with progeria caused by a defect in the transcription-coupled repair (TCR) subpathway of nucleotide excision repair (NER). Here, complete inactivation of NER in Csbm/m/Xpa-/- mutants causes a phenotype that reliably mimics th...
ORGANISM(S): Mus musculus 
2007-01-01 | E-MEXP-835 | biostudies-arrayexpress
UnknownEGFR mutations are associated with response to depatux-m in combination with temozolomide and result in a receptor that is hypersensitive to ligand.
Not available
S-EPMC7212878 | biostudies-literature
TranscriptomicsOverexpression of Musashi1 (Msi1) in HEK293T cells.
Gene expression analysis of the Msi1 overexpression in HEK 293T cells. There were two biological replicates of Msi1 and GFP (Green Fluorescent Protein) as control, used in the experiment. Each slide includes 4 microarrays with one biological sample versus control. Samples were hybridized with dye-...
ORGANISM(S): Homo sapiens 
2010-05-18 | E-GEOD-13215 | biostudies-arrayexpress
TranscriptomicsVariegated gene expression caused by cell-specific long-range DNA interactions
Mammalian genomes contain numerous DNA elements with potential transcription regulatory function but unknown target genes. We used transgenic, gain-of-function mice with an ectopic copy of the beta-globin locus control region (LCR) to better understand how regulatory elements dynamically search the ...
ORGANISM(S): Mus musculus 
2011-06-15 | E-GEOD-24614 | biostudies-arrayexpress
UnknownA standard of care for individuals with PIK3CA-related disorders: An international expert consensus statement.
Not available
S-EPMC8664971 | biostudies-literature
UnknownRandomized phase II/III trial assessing gemcitabine/carboplatin and methotrexate/carboplatin/vinblastine in patients with advanced urothelial cancer who are unfit for cisplatin-based chemotherapy: EORTC study 30986.
Not available
S-EPMC3255563 | biostudies-literature
GenomicsMeCP2 binds to 5hmC enriched within active genes and accessible chromatin in the nervous system
The high level of 5-hydroxymethylcytosine (5hmC) present in neuronal genomes suggests that mechanisms interpreting 5hmC in the central nervous system (CNS) may differ from those present in embryonic stem cells. Here we present quantitative, genome-wide analysis of 5hmC, 5- methylcytosine (5mC) an...
ORGANISM(S): Mus musculus 
2013-01-14 | E-GEOD-42880 | biostudies-arrayexpress
ProteomicsLoss of enteric neuronal Ndrg4 promotes colorectal cancer via increased release of Nid1 and Fbln2
The N-Myc Downstream-Regulated Gene 4 (NDRG4), a prominent biomarker for colorectal cancer (CRC), is specifically expressed by enteric neurons. Considering that nerves are important members of the tumor microenvironment, we here establish different Ndrg4 knockout (Ndrg4-/-) CRC models and an in-dire...
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) 
2021-04-23 | PXD024502 | Pride
Ndrg4 Fibulin-2 Extracellular matrix proteins Nidogen-1 
TranscriptomicsExpression data from Arabidopsis petioles in early stage dense canopy
Growth in dense stands induces shade avoidance responses. Early responses to neighbors seem to be assoctaed with touch, not light signalling. We studied gene expression in petioles during early canopy development when leaf hyponasty was visible but altered phytochrome signalling was not yet detectab...
ORGANISM(S): Arabidopsis thaliana 
2012-09-04 | E-GEOD-39010 | biostudies-arrayexpress
TranscriptomicsTranscription networks responsible for early regulation of Salmonella-induced inflammation in the jejunum of pigs.
The early interaction of Salmonella enterica serovar typhimurium DT104 with intact small intestinal mucosa was studied in a Small Intestinal Segment Perfusion (SISP) model. Intestinal segments were infected with or without Salmonella. Scrapings from jejunal segments were collected after perfusion fo...
ORGANISM(S): Sus scrofa 
2013-04-17 | E-GEOD-41630 | biostudies-arrayexpress
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