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UnknownCopy number variation in obsessive-compulsive disorder and tourette syndrome: a cross-disorder study.

Objective

Obsessive-compulsive disorder (OCD) and Tourette syndrome (TS) are heritable neurodevelopmental disorders with a partially shared genetic etiology. This study represents the first genome-wide investigation of large (>500 kb), rare (<1%) copy number variants (CNVs) in OCD and the la...
S-EPMC4218748 | biostudies-literature
UnknownIdentification and validation of clinical phenotypes with prognostic implications in patients admitted to hospital with COVID-19: a multicentre cohort study.

Background

The clinical presentation of COVID-19 in patients admitted to hospital is heterogeneous. We aimed to determine whether clinical phenotypes of patients with COVID-19 can be derived from clinical data, to assess the reproducibility of these phenotypes and correlation with prognosis,...
S-EPMC7906623 | biostudies-literature
UnknownPredation impact on threatened spur-thighed tortoises by golden eagles when main prey is scarce.
A reduction in adult survival in long-living species may compromise population growth rates. The spur-thighed tortoise (Testudo graeca) is a long-lived reptile that is threatened by habitat loss and fragmentation. Golden eagles (Aquila chrysaetos), whose breeding habitats overlap that of tortoises, ...
S-EPMC9596414 | biostudies-literature
UnknownClinical outcomes after CPX-351 in patients with high-risk acute myeloid leukemia: A comparison with a matched cohort from the Spanish PETHEMA registry.

Background

CPX-351 is approved for the treatment of therapy related acute myeloid leukemia (t-AML) and AML with myelodysplastic related changes (MRC-AML). The benefits of this treatment over standard chemotherapy has not been addressed in well matched cohorts of real-life patients.

Method...

S-EPMC10417130 | biostudies-literature
UnknownThrombophilia-Related Single Nucleotide Variants and Altered Coagulation Parameters in a Cohort of Mexican Women with Recurrent Pregnancy Loss.
Background: Recurrent pregnancy loss (RPL) is a multifactorial condition in which genetic variants associated with thrombophilia may contribute to altered coagulation and adverse pregnancy outcomes. Objective: This study aimed to investigate the association between thrombophilia-relate...
S-EPMC12731847 | biostudies-literature
UnknownDolutegravir plus rilpivirine: benefits beyond viral suppression: DORIPEX retrospective study.

Abstract

Switching dual therapy with dolutegravir (DTG) plus rilpivirine (RPV) was assessed in the SWORD-1 and SWORD-2 studies. Real-life data regarding the immunological impact of this approach on CD4+ and CD8+ T lymphocyte counts and the CD4/CD8 ratio are scarce. We evaluated this strategy...
S-EPMC9276328 | biostudies-literature
TranscriptomicsDifferential expression of inflammatory and immune response genes in rams experimentally infected with Brucella ovis
Infection of sheep with Brucella ovis results in ovine brucellosis, a disease characterized by infertility in rams, abortion in ewes and increased perinatal mortality in lambs. During the course of the infection both the ovine immune response and host cell gene expression are modified. The objective...
ORGANISM(S): Ovis aries 
2008-07-02 | E-GEOD-11928 | biostudies-arrayexpress
TranscriptomicsProtective response to Brucella infection
Brucella ovis causes an important disease characterized by decreased fertility in rams, sporadic abortions in ewes and increased lamb mortality. The live attenuated B. melitensis Rev.1 vaccine is considered the best vaccine available against this infection. However, this vaccine shows variable prot...
ORGANISM(S): Ovis aries 
2010-06-25 | E-GEOD-13202 | biostudies-arrayexpress
UnknownEpidemiological trends of HIV/HCV coinfection in Spain, 2015-2019.

Objectives

We assessed the prevalence of anti-hepatitis C virus (HCV) antibodies and active HCV infection (HCV-RNA-positive) in people living with HIV (PLWH) in Spain in 2019 and compared the results with those of four similar studies performed during 2015-2018.

Methods

The study was ...
S-EPMC9543728 | biostudies-literature
UnknownEconomic burden of secondary progressive multiple sclerosis: DISCOVER study.

Background

To estimate the socioeconomic burden of people with secondary progressive multiple sclerosis (pwSPMS), considering direct health care, direct non-health care, and indirect costs, and to evaluate the relationship between costs and patients' functional outcomes.

Methods

Obser...
S-EPMC11983732 | biostudies-literature
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