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TranscriptomicsTranscription profiling of E47 targets in the neuroblastoma cell line SK-N-SH at 8 hours and 20 hours
E47 is a basic Helix Loop Helix (bHLH) transcription factor that has important roles in cell fate determination and differentiation of many cell types. In the nervous system E47 heterodimerizes with tissue-specific, pro-neural bHLH transcription factors and activates downstream target genes. To iden...
ORGANISM(S): Homo sapiens 
2006-02-01 | E-MEXP-413 | biostudies-arrayexpress
GenomicChromatin Accessibility in Developing Human Brain

Non-coding regions comprise most of the human genome and harbor a significant fraction of risk alleles for neuropsychiatric diseases, yet their functions remain poorly defined. We created a high-resolution map of non-coding elements involved in human cortical neurogenesis by contrasting chromatin...

phs001438 | dbGaP
TranscriptomicsTranscriptomic signatures of risk genes implicated in psychiatric disorders during neuronal differentiation
Susceptibility genes for Autism Spectrum Disorder (ASD), Fragile X Syndrome (FXS), monogenetic disorders with intellectual disabilities (ID) or schizophrenia (SCZ) converge on processes related to neuronal function and differentiation. Furthermore, ASD risk genes are enriched for FMRP (Fragile X Men...
ORGANISM(S): Homo sapiens 
2016-06-01 | E-GEOD-69838 | biostudies-arrayexpress
TranscriptomicsA quantitative framework to evaluate modeling of cortical development by neural stem cells
In vitro neural stem cell models are widely used to model a wide range of neuropsychiatric conditions. However, how well such models correspond to in vivo brain has not been evaluated in an unbiased, comprehensive manner. We used transcriptomic analyses to compare in vitro systems to developing huma...
ORGANISM(S): Homo sapiens 
2014-06-01 | E-GEOD-57595 | biostudies-arrayexpress
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