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TranscriptomicsMicroRNAs characterize genetic diversity and drug resistance in pediatric acute lymphoblastic leukemia
MicroRNAs (miRNAs) regulate activity of protein-coding genes including those involved in hematopoietic cancers. The goal of the current study was to explore which miRNAs are unique for seven different subtypes of pediatric acute lymphoblastic leukemia (ALL). Therefore, the expression levels of 397 m...
ORGANISM(S): Homo sapiens 
2011-02-11 | E-GEOD-23024 | biostudies-arrayexpress
TranscriptomicsExpression data from ETV6-RUNX1-positive Reh leukemic cells after overexpression of miR-125b, miR-100 and miR-99a levels in different combinations
Combined overexpression of miR-125b with miR-99a and/or miR-100 induced VCR resistance in ETV6-RUNX1-positive leukemic cells Reh. We used microarrays to detail the global changes in gene expression of Reh cells upon enforced expression of miR-125 per se compared with combination of overexpression of...
ORGANISM(S): Homo sapiens 
2013-06-27 | E-GEOD-46362 | biostudies-arrayexpress
TranscriptomicsHigh VEGFC expression is associated with unique gene expression profiles and predicts adverse prognosis in pediatric and adult acute myeloid leukemia.
High VEGFC mRNA expression of AML blasts is related to increased in vitro and in vivo drug resistance. The prognostic significance of VEGFC on long-term outcome and its associated gene expression profiles remain to be defined. We studied the effect of VEGFC on treatment outcome and investigated gene...
ORGANISM(S): Homo sapiens 
2010-06-09 | E-GEOD-22056 | biostudies-arrayexpress
TranscriptomicsGene expression profiles associated with pediatric relapsed AML
In high income countries 90% of the patients achieve complete remission after induction chemotherapy. However, 30-40% of these patients suffer from relapse. These patients face a dismal prognosis, as the majority (>60%) of relapsed patients die within 5 years. As a result, outcome for pediatric acut...
ORGANISM(S): Homo sapiens 
2015-05-07 | E-GEOD-52891 | biostudies-arrayexpress
TranscriptomicsTransduced cord blood CD34+ cells with empty vector, AML1-ETO and ETV6-RUNX1
Mononuclear cells were isolated from umbilical cord blood (UCB) using Lymphoprep sucrose-gradient centrifugation (1.077 g/ml, Nycomed Pharma, Oslo, Norway). Immunomagnetic cell separation, using magnetic beads coated with CD34 antibodies (Miltenyi Biotec, Gladbach, Germany), was performed to isolate...
ORGANISM(S): Homo sapiens 
2019-01-01 | E-MTAB-3466 | biostudies-arrayexpress
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