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MetabolomicsSingle-cell time-resolved multi-omics reveal apoptotic and ferroptotic heterogeneity during foam cell formation

Macrophage-derived foam cell plays a pivotal role in the plaque formation and rupture during the progression of atherosclerosis. Foam cells are destined to divergent cell fate and functions in response to external stimuli based on their internal states, which however is hidden in the traditional ...

2023-09-08 | MTBLS6366 | MetaboLights
TranscriptomicsTHP1 derived macrophage and foam cell gene expression in presence and absence of T0901317 and RNAi analyses of LXRa/b
To assess the LXRa dependent regulatory pathways in macrophages and foam cells we treated our two, THP1 derived native and LXR-knockdown cell models either with T0901317 or vehicle control (DMSO).
ORGANISM(S): Homo sapiens 
2013-02-15 | E-MTAB-1106 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human monocyte derived macrophages reveals induction of dendritic cell-like phenotype in macrophages during foam cell formation
Foam cell formation from monocyte-derived macrophages is a hallmark of atheroscle-rotic lesions. Aspects of this process can be recapitulated in vitro by exposing MCSF-induced or platelet factor4 (CXCL4)-induced macrophages to oxidized (ox) or minimally modified (mm) low density lipoprotein (LDL). W...
ORGANISM(S): Homo sapiens 
2008-06-15 | E-GEOD-7138 | biostudies-arrayexpress
TranscriptomicsGene expression in primary human macrophages and foam cells
The aim of the experiment was to determine the effects of 48 hours of treatment with oxidized low density lipoprotein (oxLDL) on gene expression in primary human monocyte-derived macrophages. 6 independent biological replicates were processed. From each replicate half of the cells were treated with ...
ORGANISM(S): Homo sapiens 
2015-04-08 | E-GEOD-54666 | biostudies-arrayexpress
ProteomicsTMT-based quantitative proteomic profiling of human monocytes derived macrophage and foam cell
Background: Cardiovascular diseases remain the leading cause of morbidity and mortality worldwide, most of which are caused by atherosclerosis. Discerning processes that participate in macrophage-to-foam cell formation are critical for understanding the basic mechanisms underlying atherosclerosis. T...
ORGANISM(S): Homo sapiens (Human) 
2022-02-15 | PXD028363 | Pride
Atherosclerosis  macrophage  foam cell  proteome 
TranscriptomicsFoam cell specific LXRM-NM-1 ligand
OBJECTIVE: The liver X receptor M-NM-1 (LXRM-NM-1) is a ligand-dependent nuclear receptor and the major regulator of reverse cholesterol transport in macrophages. This makes it an interesting target for mechanistic study and treatment of atherosclerosis. METHODS AND RESULTS: We optimized a promising...
ORGANISM(S): Homo sapiens 
2013-09-05 | E-GEOD-39079 | biostudies-arrayexpress
TranscriptomicsLncRNA/mRNA expression profiling for THP-1 macrophages and THP-1 macrophage-derived foam cells
By identifying differentially expressed LncRNAs/mRNAs in THP-1 macrophages and THP-1 macrophage-derived foam cells, we select some differentially expressed LncRNAs and explore their roles in atherosclerosis process. We already find that some LncRNA can effect cholesterol metabolism and level of infl...
ORGANISM(S): Homo sapiens 
2014-05-20 | E-GEOD-54039 | biostudies-arrayexpress
GenomicsChromatin immunoprecipitation with next generation sequencing (ChIP-seq) of H3K27ac in primary human macrophages and foam cells
We report the enhancer landscape in primary human macrophages and foam cells using ChIP-seq for the H3K27ac histone mark CD14+ monocytes were isolated from the blood of 2 healthy male volunteers. Monocytes were differentiated into macrophages by culture for 7 days with 50ng/ml macrophage colony stim...
ORGANISM(S): Homo sapiens 
2015-04-08 | E-GEOD-54972 | biostudies-arrayexpress
GenomicsFormaldehyde-assisted isolation of regulatory elements with next generation sequencing (FAIRE-seq) in primary human macrophages and foam cells
We report the open chromatin landscape in primary human macrophages and foam cells using FAIRE-seq CD14+ monocytes were isolated from the blood of 3 healthy volunteers. Monocytes were differentiated into macrophages by culture for 7 days with 50ng/ml macrophage colony stimulating factor and then tre...
ORGANISM(S): Homo sapiens 
2015-04-08 | E-GEOD-54971 | biostudies-arrayexpress
GenomicsA study of the effect of OxLDL on C/EBP beta binding in human macrophages using chromatin immunoprecipitation for C/EBP beta with high throughput sequencing (ChIP-seq)
We report the C/EBP beta transcription factor binding landscape in human macrophages and oxLDL-induced foam cells ChIP-seq for C/EBP beta binding was performed in human macrophages and oxLDL induced-foam cells with quadruple biological replicates
ORGANISM(S): Homo sapiens 
2015-04-08 | E-GEOD-66192 | biostudies-arrayexpress
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