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MetabolomicsMechanisms of Etomidate Addiction and Neuro-Hepatic Toxicity: Molecular Pathway Analysis Based on Multi-Omics Integration
Etomidate has been linked to addictive behaviors and neurotoxic and hepatotoxic effects. We established a mouse exposure model across graded etomidate doses and assessed reward using conditioned place preference (CPP). Proteomic and metabolomic profiling of cerebral tissue and right hepatic lobe tis...
2026-09-02 | MTBLS15524 | MetaboLights
MetabolomicsMechanisms of Etomidate Addiction and Neuro-Hepatic Toxicity: Molecular Pathway Analysis Based on Multi-Omics Integration
Etomidate has been linked to addictive behaviors and neurotoxic and hepatotoxic effects. We established a mouse exposure model across graded etomidate doses and assessed reward using conditioned place preference (CPP). Proteomic and metabolomic profiling of cerebral tissue and right hepatic lobe tis...
2026-09-02 | MTBLS15525 | MetaboLights
TranscriptomicsRelationship between Differential Hepatic microRNA Expression and Decreased Hepatic Cytochrome P450 3A Activity in Cirrhosis
Background and Aim: Liver cirrhosis is associated with decreased hepatic cytochrome P4503A (CYP3A) activity but the pathogenesis of this phenomenon is not well elucidated. In this study, we examined if certain microRNAs (miRNA) are associated with decreased hepatic CYP3A activity in cirrhosis. He...
ORGANISM(S): Homo sapiens 
2013-08-15 | E-GEOD-49012 | biostudies-arrayexpress
TranscriptomicsRNA-seq of human skin lesions diagnosed as actinic keratosis, intraepidermal carcinoma or squamous cell carcinoma
We report whole tissue RNA-seq data captured from 25 AK, IEC or SCC lesions obtained from the skin of 17 individuals. We used RNA-seq to detect and measure HPV E7 transcription.
ORGANISM(S): Homo sapiens 
2018-07-09 | E-MTAB-6430 | biostudies-arrayexpress
GenomicsPLCG1 R707Q mutation is counter selected under targeted therapy in a patient with a hepatic angiosarcoma
PLCG1 R707Q mutation is counter selected under targeted therapy in a patient with a hepatic angiosarcoma
EGAS00001001281 | EGA
ProteomicsSerum proteomic profiling in patients with advanced Schistosoma japonicum-induced hepatic fibrosis
Background: Schistosoma japonicum (S. japonicum) is a parasitic flatworm that is the aetiological agent of human schistosomiasis, an important cause of hepatic fibrosis. Schistosomiasis-induced hepatic fibrosis is a consequence of the highly fibrogenic nature of egg-induced granulomatuous lesions, t...
ORGANISM(S): Homo sapiens (Human) 
2022-09-06 | PXD025224 | Pride
Quantitative proteomics Schistosomiasis-induced hepatic fibrosis 
ProteomicsProteomic analysis of mouse liver lesions at all three stages of Echinococcus granulosus infection
Infection with Echinococcus granulosus, a life-threatening zoonotic parasite, can remain asymptomatic for a long time; it is generally detectable only in the advanced stages, which delays treatment in most patients. Here, we aimed to determine what E. granulosus infection does to the host organs and...
ORGANISM(S): Echinococcus granulosus 
2024-11-07 | PXD050653 | Pride
Echinococcus granulosus infection parasite-host interaction proteomics hepatic lesions 
UnknownLeft triangular ligament lesions are likely hepatic in origin.
Not available
S-EPMC10646653 | biostudies-literature
UnknownPredictive Factors of Canine Malignant Hepatic Diseases with Multifocal Hepatic Lesions Using Clinicopathology, Ultrasonography, and Hepatobiliary Ultrasound Scores.
Not available
S-EPMC11476315 | biostudies-literature
UnknownJoint segmentation and classification of hepatic lesions in ultrasound images using deep learning.
Not available
S-EPMC8523410 | biostudies-literature
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