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MetabolomicsModulation of liver metabolism and gut microbiota by Alhagi-honey alleviated heat stress-induced liver damage

Alhagi-honey (AH) is a well-established traditional ethnic medicine with advantageous effects against diarrhea and headaches. We aim to explore the preventive effect of AH on liver damage induced by heat stress (HS) and its underlying mechanism. HS models were established by thermostat, and mice ...

2024-09-23 | MTBLS10021 | MetaboLights
MetabolomicsMicroplastics Induce Damage to Cattle and Potential Health Risks Through Microbial Mediation: A Rumen Microbiota-Gut-Liver Axis Perspective_blood

Microplastics pollution is prevalent in livestock environments, especially in ruminant feed. Exposure to microplastics can damage the gastrointestinal barrier, alter microbiota, and lead to organ damage. Despite its impact on cattle farming and potential human health risks, the effects of microp...

2025-09-08 | MTBLS12958 | MetaboLights
MetabolomicsMicroplastics Induce Damage to Cattle and Potential Health Risks Through Microbial Mediation: A Rumen Microbiota-Gut-Liver Axis Perspective_Rumen Fluid

Microplastics pollution is prevalent in livestock environments, especially in ruminant feed. Exposure to microplastics can damage the gastrointestinal barrier, alter microbiota, and lead to organ damage. Despite its impact on cattle farming and potential human health risks, the effects of micropl...

2025-09-08 | MTBLS12959 | MetaboLights
MetabolomicsGut microbiome-derived metabolites modulate intestinal epithelial cell damage and mitigate graft-versus-host disease
Not available
ORGANISM(S): Mus musculus 
ST000338 | MetabolomicsWorkbench
MetabolomicsGlycerate Production from Intestinal Fructose Metabolism Elevated by Dietary Fat Induces Glucose Intolerance Through β-cell Damage
Not available
ORGANISM(S): Mus musculus 
ST002161 | MetabolomicsWorkbench
MetabolomicsThe Effects of Combined Aerobic and Resistance Exercise on Liver Metabolomics in Mice Fed a High-Fat Diet

Background and Objectives: Obesity is often accompanied by hepatic metabolic disorders and chronic low-grade inflammation. While combined aerobic and resistance exercise is considered an intervention to improve body composition, its systematic regulatory effects on the hepatic metabolic profile r...

2026-07-11 | MTBLS15011 | MetaboLights
MetabolomicsPenthorum chinense Pursh Ameliorates Metabolic Dysfunction-Associated Alcohol-Related Liver Disease through Gut Microbiota Modulation and Metabolic Remodeling
Metabolic dysfunction-associated alcohol-related liver disease (MetALD) is characterized by hepatic steatosis, oxidative stress, inflammation, and gut microbiota dysbiosis resulting from the coexistence of metabolic dysfunction and alcohol consumption. Penthorum chinense Pursh is a traditional edibl...
2026-06-10 | MTBLS14735 | MetaboLights
MetabolomicsIntegrated multi-omics analysis of liver metabolic dysregulation in ACE2 knockout mice
This study systematically investigated the impact of ACE2 knockout (ACE2KO) on hepatic metabolic homeostasis and its molecular mechanisms, using integrated transcriptomic, proteomic, and metabolomic profiling. ACE2 deficiency exacerbates hepatic lipid accumulation, as evidenced by elevated total cho...
2025-06-23 | MTBLS12389 | MetaboLights
MetabolomicsMulti-omics uncovers formononetin's protection against antibiotic-induced liver injury via microbiota-metabolite-transcriptome coordination

Tetracycline antibiotics (TETs) cause hepatotoxicity via gut-liver axis disruption and oxidative stress. This study evaluated whether formononetin (FMN), a natural isoflavone, alleviates TET-induced liver injury through microbiota-metabolite-transcriptome coordination. Using network toxicology an...

2025-10-17 | MTBLS13161 | MetaboLights
MetabolomicsMulti-omics uncovers formononetin's protection against antibiotic-induced liver injury via microbiota-metabolite-transcriptome coordination

Tetracycline antibiotics (TETs) cause hepatotoxicity via gut-liver axis disruption and oxidative stress. This study evaluated whether formononetin (FMN), a natural isoflavone, alleviates TET-induced liver injury through microbiota-metabolite-transcriptome coordination. Using network toxicology an...

2025-10-14 | MTBLS13138 | MetaboLights
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