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MetabolomicsMulti-omics profiling identifies MAPK signaling suppression associated with tetracycline-induced root toxicity in soybean
Tetracycline (TC), a widely used veterinary antibiotic, is a pervasive emerging contaminant threatening crop production. Here, we employed integrated physiological, metabolomic, and transcriptomic analyses to decipher the response of soybean (Glycine max L.) to TC. While seed germination was unaffec...
2026-09-07 | MTBLS15077 | MetaboLights
MetabolomicsBisphenol mixture-induced DGKB downregulation promotes premature human neurogenesis through the activation of MAPK pathway

The widespread industrial transition from bisphenol A (BPA) to structural analogs such as BPS, BPE, and BPAF has raised significant concerns regarding their potential health risks. However, their neurodevelopmental risks and underlying molecular mechanisms, particularly when present as complex m...

2026-09-29 | MTBLS15671 | MetaboLights
TranscriptomicsComparative expression profiling identifies differential roles for Myogenin and p38M-NM-1 MAPK signaling in myogenesis
Mitogen activated protein kinase (MAPK) signaling regulates differentiation of many cell types. During myogenesis in particular, p38a MAPK (MAPK14) phosphorylates multiple transcriptional regulators to modulate muscle-specific gene expression. Among the p38a MAPK modulated genes is the muscle-specif...
ORGANISM(S): Mus musculus 
2012-08-01 | E-GEOD-25763 | biostudies-arrayexpress
TranscriptomicsSex-specific control of CNS autoimmunity by p38 MAPK signaling in myeloid cells
Objective: Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the central nervous system (CNS), characterized by a global increasing incidence driven by relapsing-remitting disease in females. p38 MAP kinase (MAPK) has been described as a key regulator of inflammatory respons...
ORGANISM(S): Mus musculus 
2013-10-29 | E-GEOD-51707 | biostudies-arrayexpress
MetabolomicsBrown and beige adipose tissue regulate systemic metabolism through a metabolite interorgan signaling axis
Brown and beige adipose tissue are emerging as distinct endocrine organs. These tissues are functionally associated with skeletal muscle, adipose tissue metabolism and systemic energy expenditure, suggesting an interorgan signaling network. Using metabolomics, we identify 3-methyl-2-oxovaleric acid,...
2022-03-03 | MTBLS2436 | MetaboLights
no omics definedTranscription profiling of human mesenchymal stem cells exposed to different profiles of fluid flow-induced shear stress to investigate the effects on the MARK signaling pathway
Effect of different profiles of fluid flow-induced shear stress application on MAPK pathway gene expression in human mesenchymal stem cells
ORGANISM(S): Homo sapiens 
2009-11-24 | E-MEXP-1923 | biostudies-arrayexpress
TranscriptomicsCoordinated regulation of MAPK signaling pathway and microRNA in response to ionizing radiation in lung cancer cells
microRNA regulates cellular responses to ionizing radiation (IR) through the translational control of target genes. We analyzed time-series changes in microRNA expressions upon γ-irradiation in H1299 lung cancer cell lines using microarray. Significantly changed microRNAs were selected based on ANOV...
ORGANISM(S): Homo sapiens 
2011-09-13 | E-GEOD-30075 | biostudies-arrayexpress
TranscriptomicsExpression data from MDCK cells exposed to HGF +/- MAPK inhibitors
Gene expression in Madin Darby canine kidney cells grown for 7 days to confluence on Transwell filters and exposed to HGF +/- inhibitors of the MAPK pathway (MAPK is one of the pathways activated when HGF binds to the CMET receptor tyrosine kinase). We used microarrays to detail the program of gene ...
ORGANISM(S): Canis lupus familiaris 
2010-05-25 | E-GEOD-9435 | biostudies-arrayexpress
MetabolomicsNorbergenin prevents LPS-induced inflammatory responses in macrophages through inhibiting NFkB, MAPK and STAT3 activation and blocking metabolic reprogramming

Inflammation is thought to be a key cause of many chronic diseases and cancer. However, current therapeutic agents to control inflammation have limited long-term use potential due to various side-effects. This study aimed to examine norbergenin, a constituent of traditional anti-inflammatory reci...

2023-04-06 | MTBLS7127 | MetaboLights
TranscriptomicsCritical requirement of ERK/MAPK signaling in respiratory tract development
The mammalian genome contains two ERK/MAP kinase kinase genes, Mek1 and Mek2, which encode dual-specificity kinases responsible for ERK/MAP kinase activation. To define the function of ERK/MAPK signaling pathway in lung development, we performed tissue-specific deletions of Mek1 function in a Mek...
ORGANISM(S): Mus musculus 
2014-09-02 | E-GEOD-51643 | biostudies-arrayexpress
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