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TranscriptomicsMicroarray profiling of WT or PDE10A KO mice treated with vehicle or a PDE10 inhibitor
Inhibition of phosphodiesterase 10A (PDE10A) promotes cyclic nucleotide signaling, increases striatal activation, and decreases behavioral activity. Enhanced cyclic nucleotide signaling is a well established route to producing changes in gene expression. We hypothesized that chronic suppression of P...
ORGANISM(S): Mus musculus 
2012-08-25 | E-GEOD-40377 | biostudies-arrayexpress
GenomicsPhosphodiesterase 10A (PDE10A) as a novel target to suppress β-catenin and RAS signaling in ovarian cancer
Phosphodiesterase 10A (PDE10A) as a novel target to suppress β-catenin and RAS signaling in ovarian cancer
PRJNA690803 | ENA
UnknownBiallelic Mutations in PDE10A Lead to Loss of Striatal PDE10A and a Hyperkinetic Movement Disorder with Onset in Infancy.
Not available
S-EPMC4833436 | biostudies-literature
TranscriptomicsMicroarray profiling of WT or PDE10A KO mice treated with vehicle or a PDE10 inhibitor
Inhibition of phosphodiesterase 10A (PDE10A) promotes cyclic nucleotide signaling, increases striatal activation, and decreases behavioral activity. Enhanced cyclic nucleotide signaling is a well established route to producing changes in gene expression. We hypothesized that chronic suppression of P...
ORGANISM(S): Mus musculus 
2012-08-25 | GSE40377 | GEO
UnknownPDE10A Inactivation Prevents Doxorubicin-Induced Cardiotoxicity and Tumor Growth.
Not available
S-EPMC10428174 | biostudies-literature
TranscriptomicsPhosphodiesterase 10A (PDE10A) as a novel target to suppress β-catenin and RAS signaling in ovarian cancer
The goal of this study was to investigate molecular pathways associated with PDE10A in ovarian cancer. We used CRISPR/Cas9 to knockout PDE10A in SKOV3 cells. We used the Illumina NextSeq500 to generate between 30-35 million paired end 75bp sequencing reads per sample for transcript level abundance.
ORGANISM(S): Homo sapiens 
2022-01-10 | GSE164474 | GEO
UnknownA novel thermoregulatory role for PDE10A in mouse and human adipocytes.
Not available
S-EPMC4931292 | biostudies-literature
UnknownSynthesis of Fluorine-Containing Phosphodiesterase 10A (PDE10A) Inhibitors and the In Vivo Evaluation of F-18 Labeled PDE10A PET Tracers in Rodent and Nonhuman Primate.
Not available
S-EPMC4697445 | biostudies-literature
UnknownIsolation and characterization of a dual-substrate phosphodiesterase gene family: PDE10A.
Not available
S-EPMC22059 | biostudies-literature
UnknownRole of PDE10A in vascular smooth muscle cell hyperplasia and pathological vascular remodelling.
Not available
S-EPMC9890476 | biostudies-literature
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