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TranscriptomicsEffect of repeated optogenetic stimulation on gene expression in the mouse dentate gyrus [RNA-seq]
To investigate the effect of repeated neural overactivation in the transcriptome of dentate gyrus neurons, we optogenetically stimulated mouse dentate gyrus repeatedly.
ORGANISM(S): Mus musculus 
2023-03-31 | GSE227200 | GEO
TranscriptomicsModeling SARS-CoV-2 and influenza infections and antiviral treatments in human lung epithelial tissue equivalents
Single cell RNA sequencing of human airway or human alveolar transwell tissues infected with either influenza A virus (IAV H1N1 strain A/Puerto Rico/8/1934) or SARS-CoV-2 (2019-nCoV/USA-WA1/2020)
ORGANISM(S): Homo sapiens 
2026-10-21 | GSE351695 | GEO
TranscriptomicsExtracellular Vesicles Derived from L-MYC Neural Stem Cells Mediate Neuroprotection in 3D Models of Chemotherapy- and Radiation-Induced Neurotoxicity
Background/Objectives: Cancer survivors frequently experience long-term neurocognitive impairments following chemotherapy and cranial irradiation, yet experimental models that enable mechanistic investigation of therapy-induced neurotoxicity at the transcriptional level remain limited. This study ai...
ORGANISM(S): Homo sapiens 
2026-10-21 | GSE351619 | GEO
TranscriptomicsExpression of mRNA in intestinal tissue samples from IBS-D patients and healthy subjects
IBS-D is a disease with multi-factor interaction between environment, central system, gut and gene, and its pathogenesis is relatively complex. In order to find the regulation of mRNA in the pathogenesis of IBS-D, intestinal tissue samples of IBS-D patients and healthy subjects were obtained (5 IBS-...
ORGANISM(S): Homo sapiens 
2023-03-15 | GSE212719 | GEO
TranscriptomicsGene expression profile at single cell level of B cells from the Peyer's patch (PP) in the small intestine of EWSR1 WT and BKO mice
We used single cell RNA sequencing (scRNA-seq) to analyze the diversity of PP B cells in the small intestine.
ORGANISM(S): Mus musculus 
2023-04-18 | GSE225103 | GEO
TranscriptomicsDysregulated thymus-ovary axis promotes virtual memory T cell polarization to aggravate PCOS pathology [scRNAseq-human]
Polycystic ovary syndrome (PCOS) is characterized by androgen excess, ovarian dysfunction and polycystic ovarian morphology and is classically considered as a disorder of the hypothalamic-pituitary-gonadal (HPG) axis. However, whether organs beyond the reproductive endocrine axis contribute to PCOS ...
ORGANISM(S): Homo sapiens 
2026-07-03 | GSE336823 | GEO
TranscriptomicsTotal RNA-Seq in control and TRAF4-overexpressing LNCaP cells
We reported the total gene expression in control and TRAF4-overexpressing LNCaP cells
ORGANISM(S): Homo sapiens 
2023-02-17 | GSE225509 | GEO
OtherUVDE-seq mapping of UV-induced 6-4PPs and atypical TA photoproducts
We used a novel high-throughput sequencing method known as UVDE-seq to map the formation of UV-induced 6-4 photoproducts (6-4PP) and atypical thymidine-adenine (TA) photoproducts at single nucleotide resolution across the yeast genome in wild-type and rad16 mutant cells, which are deficient in GG-NE...
ORGANISM(S): Saccharomyces cerevisiae 
2023-02-28 | GSE190471 | GEO
TranscriptomicsUnderstanding and Targeting Progression in a Novel Mouse Model of RUNX1 Familial Platelet Disorder [mouse bulk RNA]
Germline heterozygous mutations in RUNX1 are foundational for the development of familial platelet disorder (RUNX1-FPD) with predisposition to hematologic malignancies. The development of malignant disease involves the acquisition of additional somatic mutations, followed by clonal expansion. To sim...
ORGANISM(S): Mus musculus 
2026-10-08 | GSE292662 | GEO
Transcriptomics3D spheroid culture to examine adaptive therapy response in invading tumor cells
3D in vitro culture models of cancer cells in extracellular matrix (ECM) have been developed to investigate drug targeting and resistance or, alternatively, mechanisms of invasion, however models allowing analysis of shared pathways mediating invasion and therapy resistance are lacking. To evaluate ...
ORGANISM(S): Homo sapiens 
2023-04-26 | GSE215750 | GEO
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