298776 Results

Show all   Save search   Copy query
Sort   by:  
 Page size 
TranscriptomicsDynamic CD8+ T cell responses to cancer immunotherapy in human regional lymph nodes are disrupted by metastasis
CD8+ T cell responses are critical for anti-tumor immunity. While extensively profiled in the tumor microenvironment (TME), recent studies in mice identified responses in lymph nodes (LN) as essential; however, the role of LN in human cancer patients remains unknown. Here, we examined CD8+ T cells i...
ORGANISM(S): Homo sapiens 
2023-03-01 | GSE212797 | GEO
TranscriptomicsGlomerular Transcriptome in the Cprobe Cohort
We used microarrays to analyze the transcriptome of microdissected renal biopsies from patients with kidney disease and living donors. We derived pathway specific scores for Angiopoietin-Tie signaling pathway activation at mRNA level (or transcriptome level) for individual patients and studied the a...
ORGANISM(S): Homo sapiens 
2023-03-09 | GSE180393 | GEO
TranscriptomicsiPSC-derived cells lack immune tolerance to autologous NK-cells due to imbalance in ligands for activating and inhibitory NK-cell receptors
Dozens of transplants generated from pluripotent stem cells are currently in clinical trials. The creation of patient-specific iPSCs makes personalized therapy possible due to their main advantage of immunotolerance. However, some reports have claimed recently that aberrant gene expression followed ...
ORGANISM(S): Homo sapiens 
2023-03-01 | GSE212796 | GEO
TranscriptomicsSuperenhancer-activation of KLHDC8A Drives Glioma Ciliation and Hedgehog signaling
Glioblastoma ranks among the most aggressive and lethal of all human cancers, with poor responses to all therapeutic modalities. Self-renewing, highly tumorigenic glioblastoma stem cells (GSCs) contribute to therapeutic resistance and maintain cellular heterogeneity. Identification of GSC vulnerabil...
ORGANISM(S): Homo sapiens 
2022-12-22 | GSE207760 | GEO
TranscriptomicsThe meningeal transciptional response to traumatic brain injury and aging [scRNA-seq]
Emerging evidence suggests that the meningeal compartment plays instrumental roles in various neurological disorders and can modulate neurodevelopment and behavior. While this has sparked great interest in the meninges, we still lack fundamental knowledge about meningeal biology. Here, we utilized h...
ORGANISM(S): Mus musculus 
2022-12-22 | GSE206940 | GEO
TranscriptomicsMicroarray gene expression analyses of HCT116 parental and isogenic p53KO cell lines
Untreated cells were used for analysis of the basal gene expression levels in HCT116 parental and isogenic p53KO cell lines grown to confluency to elucidate the genes/pathways that are differentially regulated and dependent on the p53 pathway.
ORGANISM(S): Homo sapiens 
2023-01-02 | GSE207647 | GEO
TranscriptomicsThe discovery of the AGK inhibitor offers a targeted intervention strategy for the treatment of triple-negative breast cancer
Triple-negative breast cancer (TNBC) is highly aggressive, with a poor prognosis for patients, highlighting an urgent need for the development of safe and effective targeted intervention strategies. Through studies on specimens and clinical cases from TNBC patients, we demonstrated that acylglycerol...
ORGANISM(S): Homo sapiens 
2026-10-18 | GSE343180 | GEO
TranscriptomicsThe wheat C2H2 zinc finger protein TaZFP13D modulates the expression of chloroplast-related genes, improves growth and drought stress tolerance.
Background Maintaining global food security in the context of climate changes is an important challenge in the next century. Improving abiotic stress tolerance of major crops, like wheat, can contribute to this goal. Therefore, new genes improving tolerance to abiotic stresses, like drought, are nee...
ORGANISM(S): Triticum aestivum 
2023-03-08 | GSE226842 | GEO
TranscriptomicsSingle cell sequencing reveals sex bias in autism associated cells and genes
Here we performed single-cell RNA sequencing to examine the transcriptomes of over 45,000 cells isolated from the hippocampus of an autistic mouse model. Each cell was assigned to one of twelve major cell types based on distinct expression profiles. Differential expression analysis identified cell t...
ORGANISM(S): Mus musculus 
2023-01-30 | GSE165398 | GEO
TranscriptomicsTranscriptional profiling of Liver tissue from mice with bcatenin and Myc mutations
The effect of combinations Apc, Bcatenin and Myc mutation on mouse liver was examined with RNAseq at two time points.
ORGANISM(S): Mus musculus 
2023-04-28 | GSE230137 | GEO
Sort   by:  
 Page size