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ProteomicsTissue-regulated collagen hydroxylation at GEP/GDP motifs mediated by P4HA2
Collagen, the most abundant organic compound of vertebrate organisms, is a supramolecular protein-made polymer. Details of its subtle post-translational maturation largely determine the mechanical properties of connective tissues. Its assembly requires massive, heterogeneous prolyl-4-hydroxylation (...
ORGANISM(S): Gallus Gallus (ncbitaxon:9031) Mus Musculus (ncbitaxon:10090) 
2023-01-03 | MSV000091002 | MassIVE
ProteomicsSaLT&PepPr is an Interface-Predicting Language Model for Designing Peptide-Guided Protein Degraders
Cell lysates were adjusted to 5% SDS, and 20 ugs was reduced with 10 mM DTT and alkylated with 25 mM iodoacetamide followed by digestion with 1:15 trypsin using an S-trap at 47 degC for 1 h. Lyophilized peptides were reconstituted at 0.5 ugs/uL, and a study pool QC sample was made by mixing equal vo...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2023-10-12 | MSV000093088 | MassIVE
ProteomicsStructure of the bc1-cbb3 respiratory supercomplex from Pseudomonas aeruginosa
The sample was digested using MS-grade trypsin/Lys-C (Promega) to a final ratio of 1:20 (w/w)(SC: protease) using RapiGest SF surfactant (Waters) according to manufacturers instructions. Tryptic peptides were then separated on a 60-minute H2O: acetonitrile (ACN) gradient using a Waters ACQUITY I-Cla...
ORGANISM(S): Pseudomonas Aeruginosa Pao1 (ncbitaxon:208964) 
2023-04-27 | MSV000091814 | MassIVE
ProteomicsPolarized microtubule remodeling transforms activated microglia morphology and drives cytokine release
Microglial activation is a pathological hallmark in many neurodegenerative diseases. During activation, microglia undergo complex morphological changes, including loss of their characteristic ramified cell morphology, which is routinely used to detect and quantify inflammation in the brain. However,...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
MSV000090254 | MassIVE
ProteomicsAn EPB41L5 - YAP/TAZ- ARHGAP29 signaling axis maintains the glomerular filtration barrier in health and disease
Comparison of whole cell lysates of EPB41L5 KO and WT human podocytes by SILAC based quantitative proteomics.
ORGANISM(S): Human 
2023-02-03 | MSV000091196 | MassIVE
ProteomicsFunctional divergence of the paralogous RBM41 and U11/U12-65K proteins in the minor spliceosome
In this work, we identify RBM41 as a novel unique protein component of the minor spliceosome. RBM41 has no previously recognized cellular function but has been identified as a paralog of the U11/U12-65K protein, a known unique component of the minor spliceosome that functions during the early steps ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
MSV000092983 | MassIVE
ProteomicsIdentification of non-conventional small molecule degraders and stabilizers of squalene synthase
The dataset was obtained by performing a TMTpro16plex expression proteomics experiment, where HeLa cells were treated with small molecule ligands of squalene synthase (FDFT1). The experiment was successful in re-producing previously obtained Western Blot results in regards to SQS (=FDFT1) levels and...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2023-06-07 | MSV000092115 | MassIVE
Other20220712- Alicia Native metabolomics
Native metabolomics of Bacillus subtilis extracellular matric proteins against Bacillus and Botrytis exometabolome
ORGANISM(S): Bacillus Subtilis (ncbitaxon:1423) Botrytis Cinerea (ncbitaxon:40559) 
2022-07-13 | MSV000089878 | MassIVE
ProteomicsCalcium-dependent Ng-CaM pull down proteomics in D3 cell
Ng-CaM pull down in response to calcium concentration.
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2023-08-08 | MSV000092629 | MassIVE
ProteomicsMacrophage-to-endothelial Cell Crosstalk by 27-hydroxycholesterol Promotes Atherosclerosis in Male Mice
Human aortic endothelial cells were treated with vehicle (LUM1_S07615), estradiol (LUM1_S07617) or 27-hydroxycholesterol (LUM1_S07618), estrogen receptor alpha was immunoprecipitated, and the changes in the receptor interactome were interrogated.
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2023-05-08 | MSV000091880 | MassIVE
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