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GenomicsEHMT1 and EHMT2 inhibition induce fetal hemoglobin expression
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Homo sapiens 
2015-11-02 | E-GEOD-71422 | biostudies-arrayexpress
TranscriptomicsAttenuation of miR-126 activity expands HSC in vivo without exhaustion
Life-long blood cell production is governed through the poorly understood integration of cell-intrinsic and -extrinsic control of hematopoietic stem cell (HSC) quiescence and activation. MicroRNAs (miRNAs) coordinately regulate multiple targets within signaling networks making them attractive candid...
ORGANISM(S): Homo sapiens 
2012-11-30 | E-GEOD-40458 | biostudies-arrayexpress
GenomicsEHMT1 and EHMT2 inhibition induce fetal hemoglobin expression [ChIP-seq]
Using UNC0638 and genetic assays to inhibit EHMT1/2 and derepress fetal hemoglobin in adult hematopoietic cells. ChIP-seq for 2 histone modifications and total H3 (for quantitative normalization) in biological triplicates of cord blood, adult bone marrow, and UNC0638-treated adult bone marrow.
ORGANISM(S): Homo sapiens 
2015-11-02 | E-GEOD-69516 | biostudies-arrayexpress
TranscriptomicsEHMT1 and EHMT2 inhibition induce fetal hemoglobin expression [RNA-seq]
Using UNC0638 and genetic assays to inhibit EHMT1/2 and derepress fetal hemoglobin in adult hematopoietic cells. RNA-Seq in primary adult human erythroid cells treated with UNC0638 or the vehicle control (DMSO) in biological triplicates.
ORGANISM(S): Homo sapiens 
2015-11-02 | E-GEOD-71421 | biostudies-arrayexpress
TranscriptomicsBTG1 regulates glucocorticoid receptor autoinduction in acute lymphoblastic leukemia
RNAi mediated knockdown of BTG1 in the acute lymphoblastic cell line RS4;11 causes this cell line to become resistant to prednisolone treatment when compared to control cells. In this experiment we treated BTG1 knockdown RS4;11 cells and control RS4;11 cells either with prednisolone or a vehicle con...
ORGANISM(S): Homo sapiens 
2010-06-23 | E-GEOD-18027 | biostudies-arrayexpress
TranscriptomicsHuman hematopoietic stem cell expansion through modulation of lineage-associated gene expression programs
Hematopoietic stem cells (HSCs) must balance self-renewal and lineage differentiation to regenerate the hematopoietic system throughout life. HSCs exhibit lineage-associated gene expression that keeps them responsive to demands of mature blood production. However, it is not known whether this proces...
ORGANISM(S): Homo sapiens 
2013-12-01 | E-GEOD-45486 | biostudies-arrayexpress
GenomicsGenome-wide assessment of differential roles for p300 and CBP in transcription regulation
Through ChIP-Seq analysis with the Illumina Whole Genome Analyzer, we identify binding sites for P300 (EP300) and CBP (CREBBP) in Human glioblastoma T98G cells that were cell cycle synchronized before and after stimulation. In our analysis, we focused on the identification of genes differentially bo...
ORGANISM(S): Homo sapiens 
2010-03-30 | E-GEOD-21026 | biostudies-arrayexpress
UnknownSkewed X-inactivation is common in the general female population.
Not available
S-EPMC6460563 | biostudies-literature
TranscriptomicsmiR-126 governs human leukemia stem cell quiescence and therapeutic resistance
In acute myeloid leukemia (AML), leukemia stem cells (LSC) play a central role in disease progression and recurrence due to their intrinsic capacity for self-renewal and chemotherapy resistance. Whereas epigenetic regulation balances normal blood stem cell self-renewal and fate decisions, mutation a...
ORGANISM(S): Homo sapiens 
2016-02-01 | E-GEOD-55770 | biostudies-arrayexpress
UnknownEffect of P2Y12 Inhibitors on Survival Free of Organ Support Among Non-Critically Ill Hospitalized Patients With COVID-19: A Randomized Clinical Trial.
Not available
S-EPMC8767444 | biostudies-literature
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