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TranscriptomicsComparison of human Inflammatory and non-Inflammatory breast cancer samples
In this study we generated gene expression profiles of 41 and 55 samples of patients with and without inflammatory breast cancer (IBC vs. non-IBC). The aim of the study was to delineate the specific transcriptional profile of the samples from patients with IBC in search for diagnostic, prognostic an...
ORGANISM(S): Homo sapiens 
2012-02-23 | E-MTAB-1006 | biostudies-arrayexpress
TranscriptomicsRNA-sequencing of treatment-naive, Lapatinib-resistant, and resistant-reversal SUM149 IBC cells
In this experiment, SUM149 IBC cells were cultured using baseline medium (N=3), and in baseline medium supplemented with increasing concentration of Lapatinib to induce resistance (N=3; rSUM149). Resistant reversal SUM149 cells (rrSUM149) were then generated by culturing in rSUM149 cells in baseline...
ORGANISM(S): Homo sapiens 
2024-04-05 | E-MTAB-13929 | biostudies-arrayexpress
TranscriptomicsDNA damage responsive microRNAs misexpressed in human cancer regulate chemotherapy sensitivity (lung cancer cell lines)
The DNA damage response (DDR) is a cellular process that protects the genetic information against DNA damage and inhibits malignant transformation. Tumor cells are characterized by an aberrant DDR, which is exploited by genotoxic chemotherapy. However, cancer cells are able to develop drug resistan...
ORGANISM(S): Homo sapiens 
2013-05-31 | E-GEOD-47524 | biostudies-arrayexpress
TranscriptomicsDNA damage responsive microRNAs misexpressed in human cancer regulate chemotherapy sensitivity (HMEpC & HSAEpC)
The DNA damage response (DDR) is a cellular process that protects the genetic information against DNA damage and inhibits malignant transformation. Tumor cells are characterized by an aberrant DDR, which is exploited by genotoxic chemotherapy. However, cancer cells are able to develop drug resistan...
ORGANISM(S): Homo sapiens 
2013-05-31 | E-GEOD-47523 | biostudies-arrayexpress
TranscriptomicsDNA damage responsive microRNAs misexpressed in human cancer regulate chemotherapy sensitivity (lung tumors)
The DNA damage response (DDR) is a cellular process that protects the genetic information against DNA damage and inhibits malignant transformation. Tumor cells are characterized by an aberrant DDR, which is exploited by genotoxic chemotherapy. However, cancer cells are able to develop drug resistan...
ORGANISM(S): Homo sapiens 
2013-05-31 | E-GEOD-47525 | biostudies-arrayexpress
TranscriptomicsLoss of ZEB2 in basal breast cancer cells
Study of loss of ZEB2 in breast cancer cells in vitro and in vivo: gene expression and phenotypic switch to more benign behavior of the cancer cells. Morphological, functional and gene microarray analysis following ZEB2 knockdown in MDAMB231 cells reveals gain of epithelial differentiation, reductio...
ORGANISM(S): Homo sapiens 
2016-03-15 | E-GEOD-27966 | biostudies-arrayexpress
TranscriptomicsExpression profiling of migrated and invaded breast cancer cells predicts early metastatic relapse and reveals KrM-CM-
Cell motility and invasion initiate metastasis. However, only a subpopulation of cancer cells within a tumor will ultimately become invasive. Due to this stochastic and transient nature, in an experimental setting, migrating and invading cells need to be isolated from the general population in order...
ORGANISM(S): Homo sapiens 
2014-01-29 | E-GEOD-54465 | biostudies-arrayexpress
GenomicsBreast Cancer Histology Images
Fresh frozen breast cancer H&E tissue images collected and annotated by the International Cancer Genome Consortium (ICGC), that included the BASIS collaboration. Associated with whole genome sequence data as originally described by Nik-Zainal et al, Nature, 2016 (DOI: 10.1038/nature17676) and de...
EGAD00010001911 | EGA
GenomicsICGC breast cancer sequencing project SNP6 data
Affymetrix SNP6.0 breast cancer genome sequencing data
EGAD00010000915 | EGA
GenomicsEGAS00001000195-sc-20150416 - samples
We propose to definitively characterise the somatic genetics of breast cancer through generation of comprehensive catalogues of somatic mutations in breast cancer cases by high coverage genome sequencing coupled with integrated transcriptomic and methylation analyses.
EGAD00001001337 | EGA
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