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UnknownPractice variation in induction of labor: A critical document analysis on the contribution of regional protocols.

Rationale

Despite national guidelines with recommendations on induction of labor (IOL), large variation in the use of this intervention exists between regions in the Netherlands. Guidelines are translated into protocols, which give a contextual description of medical practice provided in a g...
S-EPMC11444378 | biostudies-literature
UnknownRegional variations in childbirth interventions in the Netherlands: a nationwide explorative study.

Background

Although interventions in childbirth are important in order to prevent neonatal and maternal morbidity and mortality, non-indicated use may cause avoidable harm. Regional variations in intervention rates, which cannot be explained by maternal characteristics, may indicate over- an...
S-EPMC5984340 | biostudies-literature
UnknownA robust pipeline with high replication rate for detection of somatic variants in the adaptive immune system as a source of common genetic variation in autoimmune disease.
The role of somatic variants in diseases beyond cancer is increasingly being recognized, with potential roles in autoinflammatory and autoimmune diseases. However, as mutation rates and allele fractions are lower, studies in these diseases are substantially less tolerant of false positives, and bio-...
S-EPMC6452186 | biostudies-literature
UnknownUnderstanding how midwife-led continuity of care can be implemented and under what circumstances: a realist review.

Objectives

To understand how and under what circumstances midwife-led continuity of care (MLCC) can be implemented in high-income countries.

Design

A realist review was conducted to examine interactions between contexts, mechanisms and outcomes.

Methods

An initial programme the...
S-EPMC11842984 | biostudies-literature
UnknownRegional variations in childbirth interventions and their correlations with adverse outcomes, birthplace and care provider: A nationwide explorative study.
BACKGROUND:Variations in childbirth interventions may indicate inappropriate use. Most variation studies are limited by the lack of adjustments for maternal characteristics and do not investigate variations in adverse outcomes. This study aims to explore regional variations in the Netherlands and th...
S-EPMC7058301 | biostudies-literature
UnknownImpaired Intestinal Farnesoid X Receptor Signaling in Cystic Fibrosis Mice.

Background & aims

The bile acid (BA)-activated farnesoid X receptor (FXR) controls hepatic BA synthesis and cell proliferation via the intestinal hormone fibroblast growth factor 19. Because cystic fibrosis (CF) is associated with intestinal dysbiosis, anomalous BA handling, and biliary cirr...
S-EPMC6881665 | biostudies-literature
UnknownCCR7 Modulates the Generation of Thymic Regulatory T Cells by Altering the Composition of the Thymic Dendritic Cell Compartment.
Upon recognition of auto-antigens, thymocytes are negatively selected or diverted to a regulatory T cell (Treg) fate. CCR7 is required for negative selection of auto-reactive thymocytes in the thymic medulla. Here, we describe an unanticipated contribution of CCR7 to intrathymic Treg generation. Ccr...
S-EPMC5639943 | biostudies-literature
UnknownPreclinical characterisation of the GM-CSF receptor as a therapeutic target in rheumatoid arthritis.

Objective

Previous work has suggested that the granulocyte macrophage colony stimulating factor (GM-CSF)-GM-CSF receptor α axis (GM-CSFRα) may provide a new therapeutic target for the treatment of rheumatoid arthritis (RA). Therefore, we investigated the cellular expression of GM-CSFRα in RA...
S-EPMC4602263 | biostudies-literature
UnknownRegional practice variation in induction of labor in the Netherlands: Does it matter? A multilevel analysis of the association between induction rates and perinatal and maternal outcomes.

Background

Practice variation in healthcare is a complex issue. We focused on practice variation in induction of labor between maternity care networks in the Netherlands. These collaborations of hospitals and midwifery practices are jointly responsible for providing high-quality maternity ca...
S-EPMC10249899 | biostudies-literature
UnknownOrganoid-guided synergistic treatment of minimal function CFTR mutations with CFTR modulators, roflumilast and simvastatin: a personalised approach.
Not available
S-EPMC10809127 | biostudies-literature
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